Your browser doesn't support javascript.
loading
Comparative Pharmacokinetics of Δ9-Tetrahydrocannabinol in Adolescent and Adult Female Mice.
Torrens, Alexa; Mabou Tagne, Alex; Tran, Adren; Ahmed, Faizy; Huestis, Marilyn A; Piomelli, Daniele.
Afiliación
  • Torrens A; Department and Anatomy and Neurobiology, University of California, Irvine, California, USA.
  • Mabou Tagne A; Department and Anatomy and Neurobiology, University of California, Irvine, California, USA.
  • Tran A; Department and Anatomy and Neurobiology, University of California, Irvine, California, USA.
  • Ahmed F; Department and Anatomy and Neurobiology, University of California, Irvine, California, USA.
  • Huestis MA; Institute of Emerging Health Professions, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
  • Piomelli D; Department and Anatomy and Neurobiology, University of California, Irvine, California, USA.
Cannabis Cannabinoid Res ; 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39162003
ABSTRACT

Introduction:

Animal studies suggest that adolescent exposure to Δ9-tetrahydrocannabinol (Δ9-THC), the intoxicating constituent of cannabis, causes lasting functional alterations in brain and other organs. Those studies often neglect the impact that age- and sex-dependent differences in the distribution and metabolism of the drug might exert on its pharmacological effects. Here, we provide a comparative analysis of Δ9-THC pharmacokinetics in adolescent and adult female mice, which identify significant dissimilarities in distribution and metabolism of Δ9-THC between females of these age groups. Materials and

Methods:

We administered Δ9-THC (5 mg/kg, intraperitoneal) to adolescent (37-day old) and young adult (70-day old) female mice and quantified Δ9-THC and its first-pass metabolites-11-hydroxy-Δ9-THC (11-OH-THC) and 11-nor-9-carboxy-Δ9-THC (11-COOH-THC)-in plasma and brain tissue using liquid chromatography/tandem mass spectrometry.

Results:

Maximal plasma concentrations of Δ9-THC were 8 times higher in adolescent than adult female mice. Conversely, brain concentrations and brain-to-plasma ratios were 25-50% higher in adults than adolescents. Concentrations of Δ9-THC metabolites were higher in plasma but lower in brain of adolescent compared to adult female mice.

Conclusions:

The results identify multiple age-dependent differences in the pharmacokinetic properties of Δ9-THC in female mice, which might influence the pharmacological response to the drug.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cannabis Cannabinoid Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cannabis Cannabinoid Res Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos