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Reticular Pseudodrusen: Impact of Their Presence and Extent on Local Rod Function in Age-Related Macular Degeneration.
Kumar, Himeesh; Guymer, Robyn H; Hodgson, Lauren A B; Hadoux, Xavier; Jannaud, Maxime; van Wijngaarden, Peter; Luu, Chi D; Wu, Zhichao.
Afiliación
  • Kumar H; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Guymer RH; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia.
  • Hodgson LAB; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Hadoux X; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia.
  • Jannaud M; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • van Wijngaarden P; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
  • Luu CD; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia.
  • Wu Z; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Ophthalmol Sci ; 4(6): 100551, 2024.
Article en En | MEDLINE | ID: mdl-39161750
ABSTRACT

Purpose:

To understand the spatial relationship between local rod-mediated visual function and reticular pseudodrusen (RPD) in eyes with large drusen.

Design:

Retrospective cross-sectional study.

Participants:

One eye with large drusen (>125 µm) each from 91 individuals with intermediate age-related macular degeneration, with and without RPD.

Methods:

All participants underwent dark adaptation testing using a dark-adapted chromatic perimeter, where visual sensitivities were measured over 30 minutes of dark adaptation after photobleach. The rod intercept time (RIT; a measure of dynamic rod function) and pointwise sensitivity difference (PWSD; a relative measure of rod- compared with cone-mediated function) was determined at multiple retinal locations, and their association with the overall (central 20° × 20° region) and local (2° diameter region centered on the location tested) extent of RPD and drusen (quantified using multimodal imaging) was examined. Main Outcome

Measures:

Association between overall and local extent of RPD and drusen with RIT and PWSD at each retinal location tested.

Results:

In a multivariable analysis, delayed RIT was associated with an increasing overall (P < 0.001), but not local (P = 0.884), extent of RPD. In contrast, the increasing local (P < 0.001), but not overall (P = 0.475), extent of drusen was associated with delayed RIT. Furthermore, only an increasing overall extent of RPD (P < 0.001) was associated with reduced PWSD (or worse rod compared with cone function), but not the local extent of RPD and drusen, or overall extent of drusen (P ≥ 0.344).

Conclusions:

Local rod-mediated function was associated with the overall, rather than local, extent of RPD in eyes with large drusen, suggesting that there may be widespread pathologic changes in eyes with RPD that account for this. Financial Disclosures Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ophthalmol Sci Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ophthalmol Sci Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Países Bajos