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Extreme founder effect associated with hyperglycemia and hyperlipidemia on the island of NIAS/Indonesia.
Kennerknecht, Ingo; Hämmerle, Johannes M; Fobker, Manfred; Nofer, Jerzy-Roch.
Afiliación
  • Kennerknecht I; Institute of Human Genetics, University of Münster, Münster, Germany.
  • Hämmerle JM; Yayasan Pusaka Nias (YPN), Gunungsitoli, Sumatera Utara, Indonesia.
  • Fobker M; Central Laboratory Facility, University Hospital Münster, Münster, Germany.
  • Nofer JR; Central Laboratory Facility, University Hospital Münster, Münster, Germany.
Atheroscler Plus ; 57: 26-29, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39161624
ABSTRACT
The island of Nias/Indonesia shows an extremely reduced genetic diversity indicating a strong founder effect. As a consequence, the prevalence of some disease genes should significantly differ among populations depending on the gene pool passed on to the founder population and their successive expansion as it has already been documented for several monogenic diseases. Results of the current study based on routine laboratory blood examination give rise to the notion that this might also hold true for polygenic disorders. We observed very high prevalence of hyperglycemia (non-fasting glucose above 200 mg/dL in 14 % Nias population compared to 1.5 % in the population of the neighboring island of Sumatra) accompanied by hypertriglyceridemia, high non-HDL-cholesterol, and low HDL-cholesterol levels. These findings suggest that the Nias population may be disproportionally affected by prediabetes and type 2 diabetes mellitus. By contrast, laboratory parameters potentially indicative of other polygenic disorders such as total plasma cholesterol, electrolytes, creatinine, urea, and uric acid were comparable between the inhabitants of Nias and Sumatra islands. To our knowledge this is the first study suggesting that the extremely strong genetic bottleneck seen in the Nias population translates into the widespread metabolic disease with potentially deleterious influence on public health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Atheroscler Plus Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Atheroscler Plus Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos