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COVID-19 throughout pandemic waves and virus variants: a real-life experience in an Italian hospital.
Dettori, Silvia; Brucci, Giorgia; Portunato, Federica; Ponzano, Marta; Magnasco, Laura; Mirabella, Michele; Magnè, Federica; Delfino, Emanuele; Balletto, Elisa; Sepulcri, Chiara; Vena, Antonio; Giacobbe, Daniele Roberto; Marelli, Cristina; Ball, Lorenzo; Mikulska, Malgorzata; Di Biagio, Antonio; Bruzzone, Bianca; Signori, Alessio; Mora, Sara; Giacomini, Mauro; Dentone, Chiara; Bassetti, Matteo.
Afiliación
  • Dettori S; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Brucci G; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Portunato F; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Ponzano M; Section of Biostatistics, Department of Health Sciences, University of Genoa, Genoa, Italy.
  • Magnasco L; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Mirabella M; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Magnè F; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Delfino E; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Balletto E; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Sepulcri C; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Vena A; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Giacobbe DR; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Marelli C; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Ball L; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Mikulska M; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Di Biagio A; Anesthesia and Intensive Care, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Bruzzone B; Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
  • Signori A; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Mora S; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Giacomini M; Infectious Diseases Unit, IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.
  • Dentone C; Department of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
  • Bassetti M; Hygiene Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
J Chemother ; : 1-9, 2024 Aug 19.
Article en En | MEDLINE | ID: mdl-39161053
ABSTRACT
New therapies and vaccines changed the management of COVID-19. The aim of this retrospective study was to describe characteristics, in-hospital mortality and its predictors in patients with moderate/severe COVID-19, considering the 4 different pandemic waves and viral variants' prevalence from February 2020 to January 2022. Among 1135 patients included, 873 (77%) had at least one comorbidity, 177 (16%) were immunocompromised. From waves 1 to 4, patients with severe respiratory failure and ICU admission decreased over time (p < 0.001), like the length of in-hospital stay (p < 0.001). Despite a reduction of in-hospital mortality from 19% to 11%, increased risk of death was related to older age and immunocompromising conditions, especially during the 4th wave (HR = 5.07 and HR = 10.86, p < 0.001 respectively) while remdesivir treatment in the 3rd wave (HR = 0.41, p = 0.010) and positive serology (aHR = 0.66, p = 0.027) were protective for survival. These data support the need for tailoring vaccine campaign for future COVID-19 waves.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Chemother Asunto de la revista: ANTINEOPLASICOS / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Chemother Asunto de la revista: ANTINEOPLASICOS / TERAPIA POR MEDICAMENTOS Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido