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Mechanical pain sensitivity is associated with hippocampal structural integrity.
Ayoub, Lizbeth J; Honigman, Liat; Barnett, Alexander J; McAndrews, Mary Pat; Moayedi, Massieh.
Afiliación
  • Ayoub LJ; Centre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
  • Honigman L; Division of Clinical and Computational Neuroscience, Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
  • Barnett AJ; University of Toronto Centre for the Study of Pain, University of Toronto, Toronto, ON, Canada.
  • McAndrews MP; Centre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
  • Moayedi M; Department of Psychology, Faculty of Arts and Science, University of Toronto, Toronto, ON, Canada.
Pain ; 165(9): 2079-2086, 2024 09 01.
Article en En | MEDLINE | ID: mdl-39159941
ABSTRACT
ABSTRACT Rodents and human studies indicate that the hippocampus, a brain region necessary for memory processing, responds to noxious stimuli. However, the hippocampus has yet to be considered a key brain region directly involved in the human pain experience. One approach to answer this question is to perform quantitative sensory testing on patients with hippocampal damage-ie, medial temporal lobe epilepsy. Some case studies and case series have performed such tests in a handful of patients with various types of epilepsy and have reported mixed results. Here, we aimed to determine whether mechanical pain sensitivity was altered in patients diagnosed with temporal lobe epilepsy. We first investigated whether mechanical pain sensitivity in patients with temporal lobe epilepsy differs from that of healthy individuals. Next, in patients with temporal lobe epilepsy, we evaluated whether the degree of pain sensitivity is associated with the degree of hippocampal integrity. Structural integrity was based on hippocampal volume, and functional integrity was based on verbal and visuospatial memory scores. Our findings show that patients with temporal lobe epilepsy have lower mechanical pain sensitivity than healthy individuals. Only left hippocampal volume was positively associated with mechanical pain sensitivity-the greater the hippocampal damage, the lower the sensitivity to mechanical pain. Hippocampal measures of functional integrity were not significantly associated with mechanical pain sensitivity, suggesting that the mechanisms of hippocampal pain processing may be different than its memory functions. Future studies are necessary to determine the mechanisms of pain processing in the hippocampus.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Umbral del Dolor / Epilepsia del Lóbulo Temporal / Hipocampo Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pain Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Umbral del Dolor / Epilepsia del Lóbulo Temporal / Hipocampo Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Pain Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos