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Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma.
Machado, Marta Evangelho; Porto, Luis C; Nogueira, Jeane S; Sant Anna, Clemax C; Lapa E Silva, José R.
Afiliación
  • Machado ME; Universidade Federal do Rio de Janeiro (UFRJ), Programa de Pós-graduação em Clínica Médica (PPGCM - HU), Rio de Janeiro, RJ, Brazil; Fundação Técnico-Educacional Souza Marques, Departamento de Pediatria - Pólo Itanhangá, Rio de Janeiro, RJ, Brazil. Electronic address: memaocj@hotmail.com.
  • Porto LC; Universidade do Estado do Rio de Janeiro (UERJ), Laboratório de Histocompatibilidade e Criopreservação (HLA - PPC), Rio de Janeiro, RJ, Brazil.
  • Nogueira JS; Universidade do Estado do Rio de Janeiro (UERJ), Laboratório de Histocompatibilidade e Criopreservação (HLA - PPC), Rio de Janeiro, RJ, Brazil.
  • Sant Anna CC; Universidade Federal do Rio de Janeiro (UFRJ), Programa de Pós-graduação em Clínica Médica (PPGCM - HU), Rio de Janeiro, RJ, Brazil.
  • Lapa E Silva JR; Universidade Federal do Rio de Janeiro (UFRJ), Programa de Pós-graduação em Clínica Médica (PPGCM - HU), Rio de Janeiro, RJ, Brazil.
J Pediatr (Rio J) ; 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-39159917
ABSTRACT

OBJECTIVE:

To describe independent factors related to the interaction of FTO rs9939609, TMEM18 rs6548238, leptin, and adiponectin in children/adolescents with asthma, under the influence of obesity.

METHODS:

The authors performed a cross-sectional study with 57 children/adolescents, ages 8-19 years, at a tertiary hospital, from 2017 to 2018. Participants were classified by nutritional status, performed spirometry with a bronchodilator test and completed an asthma questionnaire, higher scores indicated more asthma symptoms. Two asthma groups were formed Group 1(G1)-normal-weight; Group 2(G2)-overweight/obese. Serum was collected for adipokines (n = 32) and genetic polymorphisms (n = 53) dosages.

RESULTS:

Age and body mass index (BMI) correlated directly in normal-weight (p = 0.009) and obese participants (p = 0.004). Girls reported more asthma complaints (p = 0.044). Participants with negative bronchodilator responses presented lower BMI (14.55-17.16) than responders (19.4-26.84) (p = 0.049). Leptin dosages are related directly to BMI (5,34-40 ng/ml in obese × 0,54-42 ng/ml in nonobese) (p = 0.003). Levels were high in girls (4.78-17.55 µg/ml) (p = 0.029) and low in nonobese boys (0.54-6.92 µg/ml) (p = 0.006). In obese, low leptin levels (< 10 ng/ml) were found in small airway dysfunction carriers (p = 0.025); elevated adiponectin (> 5 µg/ml) correlated with FEV1/FVC > 80 % (p = 0.035) and positive bronchodilator tests (8.84-13 µg/ml) (p = 0.039); and FTO A allele correlated with low adiponectin 0-8.84 µg/ml (p = 0.021) and low FEV1/FVC (46 %-88 %) (p = 0.023).

CONCLUSION:

BMI correlated directly with age and leptin levels. Obese participants presented high serum levels of leptin and FTO A allele correlated with low FEV1/FVC. Larger cohorts are necessary for better elucidation of the role of adipokines and polymorphisms in the pathophysiology of asthma and obesity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Pediatr (Rio J) Año: 2024 Tipo del documento: Article Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Pediatr (Rio J) Año: 2024 Tipo del documento: Article Pais de publicación: Brasil