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White matter and latency of visual evoked potentials during maturation: A miniature pig model of adolescent development.
Kochunov, Peter; Hong, L Elliot; Summerfelt, Ann; Gao, Si; Brown, P Leon; Terzi, Matthew; Acheson, Ashley; Woldorff, Marty G; Fieremans, Els; Abdollahzadeh, Ali; Sathyasaikumar, Korrapati V; Clark, Sarah M; Schwarcz, Robert; Shepard, Paul D; Elmer, Greg I.
Afiliación
  • Kochunov P; Faillace Department of Psychiatry and Behavioral Sciences at McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic
  • Hong LE; Faillace Department of Psychiatry and Behavioral Sciences at McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Summerfelt A; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Gao S; Faillace Department of Psychiatry and Behavioral Sciences at McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Brown PL; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Terzi M; Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Acheson A; Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Woldorff MG; Center for Cognitive Neuroscience, Duke University, Durham, NC. USA.
  • Fieremans E; Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA.
  • Abdollahzadeh A; Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA.
  • Sathyasaikumar KV; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Clark SM; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Schwarcz R; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Shepard PD; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Elmer GI; Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
J Neurosci Methods ; 411: 110252, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39159872
ABSTRACT

BACKGROUND:

Continuous myelination of cerebral white matter (WM) during adolescence overlaps with the formation of higher cognitive skills and the onset of many neuropsychiatric disorders. We developed a miniature-pig model of adolescent brain development for neuroimaging and neurophysiological assessment during this critical period. Minipigs have gyroencephalic brains with a large cerebral WM compartment and a well-defined adolescence period.

METHODS:

Eight Sinclair™ minipigs (Sus scrofa domestica) were evaluated four times during weeks 14-28 (40, 28 and 28 days apart) of adolescence using monocular visual stimulation (1 Hz)-evoked potentials and diffusion MRI (dMRI) of WM. The latency for the pre-positive 30 ms (PP30), positive 30 ms (P30) and negative 50 ms (N50) components of the flash visual evoked potentials (fVEPs) and their interhemispheric latency (IL) were recorded in the frontal, central and occipital areas during ten 60-second stimulations for each eye. The dMRI imaging protocol consisted of fifteen b-shells (b = 0-3500 s/mm2) with 32 directions/shell, providing measurements that included fractional anisotropy (FA), radial kurtosis, kurtosis anisotropy (KA), axonal water fraction (AWF), and the permeability-diffusivity index (PDI).

RESULTS:

Significant reductions (p < 0.05) in the latency and IL of fVEP measurements paralleled significant rises in FA, KA, AWF and PDI over the same period. The longitudinal latency changes in fVEPs were primarily associated with whole-brain changes in diffusion parameters, while fVEP IL changes were related to maturation of the corpus callosum.

CONCLUSIONS:

Good agreement between reduction in the latency of fVEPs and maturation of cerebral WM was interpreted as evidence for ongoing myelination and confirmation of the minipig as a viable research platform. Adolescent development in minipigs can be studied using human neuroimaging and neurophysiological protocols and followed up with more invasive assays to investigate key neurodevelopmental hypotheses in psychiatry.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Porcinos Enanos / Imagen de Difusión por Resonancia Magnética / Potenciales Evocados Visuales / Sustancia Blanca Límite: Animals Idioma: En Revista: J Neurosci Methods Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Porcinos Enanos / Imagen de Difusión por Resonancia Magnética / Potenciales Evocados Visuales / Sustancia Blanca Límite: Animals Idioma: En Revista: J Neurosci Methods Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos