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Characteristics of Nocturnal Hypoglycaemic Events and Their Impact on Glycaemia.
Eichenlaub, Manuel; Öter, Sükrü; Waldenmaier, Delia; Kulzer, Bernd; Heinemann, Lutz; Ziegler, Ralph; Schnell, Oliver; Glatzer, Timor; Freckmann, Guido.
Afiliación
  • Eichenlaub M; Institut für Diabetes-Technologie, Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm, Ulm, Germany.
  • Öter S; Institut für Diabetes-Technologie, Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm, Ulm, Germany.
  • Waldenmaier D; Institute for General Physiology, Ulm University, Ulm, Germany.
  • Kulzer B; Institut für Diabetes-Technologie, Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm, Ulm, Germany.
  • Heinemann L; Research Institute Diabetes Academy Mergentheim, Bad Mergentheim, Germany.
  • Ziegler R; Diabetes Center Mergentheim, Bad Mergentheim, Germany.
  • Schnell O; Department of Clinical Psychology and Psychotherapy, University of Bamberg, Bamberg, Germany.
  • Glatzer T; Science Consulting in Diabetes GmbH, Düsseldorf, Germany.
  • Freckmann G; Diabetes Clinic for Children and Adolescents, Muenster, Germany.
J Diabetes Sci Technol ; 18(5): 1035-1043, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39158983
ABSTRACT

BACKGROUND:

Nocturnal hypoglycaemia is a burden for people with diabetes, particularly when treated with multiple daily injections (MDI) therapy. However, the characteristics of nocturnal hypoglycaemic events in this patient group are only poorly described in the literature.

METHOD:

Continuous glucose monitoring (CGM) data from 185 study participants with type 1 diabetes using MDI therapy were collected under everyday conditions for up to 13 weeks. Hypoglycaemic events were identified as episodes of consecutive CGM readings <70 mg/dl or <54 mg/dl for at least 15 minutes. Subsequently, the time <54 mg/dl (TB54), time below range (TBR), time in range (TIR), time above range (TAR), glucose coefficient of variation (CV), and incidence of hypoglycaemic events were calculated for diurnal and nocturnal periods. Furthermore, the effect of nocturnal hypoglycaemic events on glucose levels the following day was assessed.

RESULTS:

The incidence of hypoglycaemic events <70 mg/dl was significantly lower during the night compared to the day, with 0.8 and 3.8 events per week, respectively, while the TBR, TB54, and incidence of events with CGM readings <54 mg/dl was not significantly different. Nocturnal hypoglycaemic events <70 mg/dl were significantly longer (60 vs 35 minutes) and enveloped by less rapidly changing glucose levels. On days following nights containing hypoglycaemic events, there was a decrease in TAR, mean CGM glucose level and morning glucose levels and an increase in TB54, TBR, and CV.

CONCLUSIONS:

The results showed that nocturnal hypoglycaemic events are a common occurrence in persons with type 1 diabetes using MDI with significant differences between the characteristics of nocturnal and diurnal events.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Automonitorización de la Glucosa Sanguínea / Ritmo Circadiano / Diabetes Mellitus Tipo 1 / Hipoglucemia / Hipoglucemiantes Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Diabetes Sci Technol Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Automonitorización de la Glucosa Sanguínea / Ritmo Circadiano / Diabetes Mellitus Tipo 1 / Hipoglucemia / Hipoglucemiantes Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Diabetes Sci Technol Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos