Your browser doesn't support javascript.
loading
Hypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large-Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status.
Hamam, Omar; Gudenkauf, Julie; Moustafa, Rawan; Cho, Andrew; Montes, Daniel; Sharara, Muhannad; Moustafa, Abdallah; Radmard, Mahla; Nabi, Mehreen; Chen, Kevin; Sepehri, Sadra; Shin, Christopher; Mazumdar, Ishan; Kim, Minsoo; Mohseni, Alireza; Malhotra, Ajay; Romero, Javier; Yedavalli, Vivek.
Afiliación
  • Hamam O; Department of Radiology, Massachusetts General Hospital Harvard Medical School Boston MA.
  • Gudenkauf J; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Moustafa R; Department of Cardiovascular Medicine Robert Wood Johnson Medical School New Brunswick NJ.
  • Cho A; School of Arts and Sciences Rutgers University-Newark Newark NJ.
  • Montes D; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Sharara M; Radiology Resident University of Colorado, Anschutz Medical Campus Aurora CO.
  • Moustafa A; Georgia Cancer Center August University Augusta GA.
  • Radmard M; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Nabi M; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Chen K; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Sepehri S; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Shin C; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Mazumdar I; Lahey Hospital and Medical Center Burlington MA.
  • Kim M; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Mohseni A; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Malhotra A; Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore MD.
  • Romero J; Yale School of Medicine New Haven CT.
  • Yedavalli V; Department of Radiology, Massachusetts General Hospital Harvard Medical School Boston MA.
J Am Heart Assoc ; 13(16): e030897, 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39158547
ABSTRACT

BACKGROUND:

Collateral status (CS) plays a crucial role in infarct growth rate, risk of postthrombectomy hemorrhage, and overall clinical outcomes in patients with acute ischemic stroke (AIS) secondary to anterior circulation large-vessel occlusions (LVOs). Hypoperfusion intensity ratio has been previously validated as an indirect noninvasive pretreatment imaging biomarker of CS. In addition to imaging, derangements in admission laboratory findings can also influence outcomes in patients with AIS-LVO. Therefore, our study aims to assess the relationship between admission laboratory findings, baseline characteristics, and CS, as assessed by hypoperfusion intensity ratio in patients with AIS-LVO. METHODS AND

RESULTS:

In this retrospective study, consecutive patients presenting with AIS secondary to anterior circulation LVO who underwent pretreatment computed tomography perfusion were included. The computed tomography perfusion data processed by RAPID (Ischema View, Menlo Park, CA) generated the hypoperfusion intensity ratio. Binary logistic regression models were used to assess the relationship between patients' baseline characteristics, admission laboratory findings, and poor CS. A total of 221 consecutive patients with AIS-LVO between January 2017 and September 2022 were included in our study (mean±SD age, 67.0±15.8 years; 119 men [53.8%]). Multivariable logistic regression showed that patients with AIS caused by cardioembolic and cryptogenic causes (adjusted odds ratio [OR], 2.67; 95% CI, 1.20-5.97; P=0.016), those who presented with admission National Institutes of Health Stroke Scale score ≥12 (adjusted OR, 3.12; 95% CI, 1.61-6.04; P=0.001), and male patients (adjusted OR, 2.06; 95% CI, 1.13-3.77; P=0.018) were associated with poor CS.

CONCLUSIONS:

Stroke caused by cardioembolic or cryptogenic causes, admission National Institutes of Health Stroke Scale score of ≥12, and male sex were associated with poor CS, as defined by hypoperfusion intensity ratio in the patients with AIS-LVO.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Circulación Cerebrovascular / Circulación Colateral / Accidente Cerebrovascular Isquémico Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Circulación Cerebrovascular / Circulación Colateral / Accidente Cerebrovascular Isquémico Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Am Heart Assoc Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido