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Peptide-based supramolecular hydrogels and their biotherapeutic applications.
Wu, Chengfan; Liao, Wenjie; Zhang, Yujia; Yan, Yunfeng.
Afiliación
  • Wu C; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yfyan@zjut.edu.cn.
  • Liao W; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yfyan@zjut.edu.cn.
  • Zhang Y; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yfyan@zjut.edu.cn.
  • Yan Y; College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, P. R. China. yfyan@zjut.edu.cn.
Biomater Sci ; 12(19): 4855-4874, 2024 Sep 25.
Article en En | MEDLINE | ID: mdl-39158039
ABSTRACT
In recent years, supramolecular hydrogels have made groundbreaking research progress in biomedical fields such as drug delivery, biosensing, imaging analysis, and tissue engineering. Peptides, with their unique characteristics of facile preparation, low immunogenicity and easy biodegradability, are commonly used as building blocks of supramolecular hydrogels. Peptide-based supramolecular hydrogels loaded with drugs, prepared via physical means or covalent crosslinking, exhibit unique three-dimensional network structures and strong water retention capacities. These properties enhance drug bioavailability and reduce side effects, enabling drug accumulation and responsive release at disease sites, significantly improving the therapeutic efficacy. Here, we review recent advancements in peptide-based supramolecular hydrogels and their biotherapeutic applications, including chemotherapy, photothermal therapy, photodynamic therapy, immunotherapy, gene therapy, antibacterial and anti-inflammatory treatments, and other biological applications. This review aims to provide new inspiration for the development of biomaterials in the therapeutic field and provide more personalized options for disease treatment. Additionally, challenges and limitations in this field are briefly discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Hidrogeles Límite: Animals / Humans Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Hidrogeles Límite: Animals / Humans Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido