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ICP5249 Promotes Hair Growth by Activating the AMPK-Autophagy Signaling Pathway.
Lee, Jung Ok; Kim, Yu-Jin; Jang, You Na; Lee, Jung Min; Shin, Kayoung; Jeong, Sekyoo; Chung, Hwa-Jee; Kim, Beom Joon.
Afiliación
  • Lee JO; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.
  • Kim YJ; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.
  • Jang YN; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.
  • Lee JM; Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 06974, Republic of Korea.
  • Shin K; Department of Medicine, Graduate School, Chung-Ang University, Seoul 06973, Republic of Korea.
  • Jeong S; R&D Center, Incospharm Corporation, Daejeon 34000, Republic of Korea.
  • Chung HJ; R&D Center, Incospharm Corporation, Daejeon 34000, Republic of Korea.
  • Kim BJ; R&D Center, Incospharm Corporation, Daejeon 34000, Republic of Korea.
J Microbiol Biotechnol ; 34(9): 1-9, 2024 Jul 26.
Article en En | MEDLINE | ID: mdl-39155393
ABSTRACT
Autophagy is essential for regulating hair growth. Accordingly, we developed autophagy activator ICP5249 (pentasodium tetracarboxymethyl palmitoyl dipeptide) and investigated its potential role in hair growth. We evaluated its effect on hair growth using in vitro human dermal papilla cells (hDPCs) culture model, human hair follicles (hHFs) organ culture model, and telogenic mouse model. ICP5249 increased hDPCs proliferation and alkaline phosphatase (ALP) expression. It also increased microtubule-associated protein (MAP) light chain 3- II (LC3-II) expression and AMP-activated protein kinase α (AMPKα) and unc-51-like kinase 1 (ULK1) phosphorylation in hDPCs. ICP5249 extended the length of hHFs and increased LC3 II expression. Consistently, ICP5249 also significantly increased hair growth area, dermis thickness, and anagen and telogen ratio in telogenic mice. Furthermore, it upregulated Ki-67 and LC3-II expression and AMPKα phosphorylation on the mice's dorsal skin. To investigate whether AMPK regulates ICP5249-induced hair growth, following treatment with the compound C, AMPK inhibitor, the activity of ICP5249 was evaluated. The effects of ICP5249 on hair growth were assessed following pretreatment with the AMPK inhibitor compound C. The results showed that compound C suppressed ICP5249-mediated proliferation and hair inductivity in hDPCs. Additionally, compound C inhibited ICP5249-mediated hair growth area, dermis thickness, anagen and telogen ration, and LC3-II expression in mice, suggesting that ICP5249 promotes hair growth by modulating autophagy, with AMPKα playing a regulatory role in this process. Taken together, we demonstrate that ICP5249 has the potential as an ingredient for improving hair growth.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Microbiol Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Microbiol Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación: