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Young (<35 years) haploidentical versus old (≥35 years) mismatched unrelated donors and vice versa for allogeneic stem cell transplantation with post-transplant cyclophosphamide in patients with acute myeloid leukemia in first remission: a study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.
Nagler, Arnon; Labopin, Myriam; Swoboda, Ryszard; Blaise, Didier; Angelucci, Emanuele; Vydra, Jan; Corral, Lucía López; Bramanti, Stefania; Chiusolo, Patrizia; Kwon, Mi; Koc, Yener; Itäla-Remes, Maija; Martino, Massimo; Kulagin, Alexander; Busca, Alessandro; Ciceri, Fabio; Mohty, Mohamad.
Afiliación
  • Nagler A; Division of Hematology, Sheba Medical Center, Tel Hashomer, Israel. arnon.nagler@sheba.health.gov.il.
  • Labopin M; Department of Hematology, EBMT Paris Study Office, Saint Antoine Hospital, INSERM UMR 938, Sorbonne University, Paris, France.
  • Swoboda R; Department of Hematology, Saint Antoine Hospital, INSERM UMR 938, Sorbonne University, Paris, France.
  • Blaise D; Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
  • Angelucci E; Programme de Transplantation & Therapie Cellulaire, Marseille, France.
  • Vydra J; Ospedale San Raffaele s.r.l., Milano, Italy.
  • Corral LL; Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
  • Bramanti S; Hospital Clínico, Salamanca, Spain.
  • Chiusolo P; Transplantation Unit Department of Oncology and Haematology, IRCCS Humanitas Research Hospital, Milan, Italy.
  • Kwon M; Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, Rome, Italy.
  • Koc Y; Department of Hematology, Hospital General Universitario Gregorio Marañon, Institute of Health Research Gregorio Marañon, Madrid, Spain.
  • Itäla-Remes M; Medicana International Hospital Istanbul, Istanbul, Turkey.
  • Martino M; Turku University Hospital, Turku, Finland.
  • Kulagin A; Stem Cell Transplantation and Cellular Therapies Unit (CTMO), Department of Hemato-Oncology and Radiotherapy, Grande Ospedale Metropolitano "Bianchi-Melacrino-Morelli", Reggio Calabria, Italy.
  • Busca A; RM Gorbacheva Research Institute, Pavlov University, Petersburg, Russian Federation.
  • Ciceri F; S.S.C.V. D Trapianto di Cellule Staminali, Torino, Italy.
  • Mohty M; IRCCS Osspedale San Raffaele, Vita-Salute San Raffaele University Hematology and BMT, Milano, Italy.
Bone Marrow Transplant ; 59(11): 1552-1562, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39155338
ABSTRACT
We compared transplantation (HSCT) outcomes in AML patients undergoing HSCT with post-transplant cyclophosphamide (PTCy) in first complete remission from 1065 young (<35 years) haploidentical (Haplo) donors (yHaplo) vs. 147 old (≥35 years) mismatched unrelated donors (oMMUD) (first comparison) and from 271 young (<35 years) MMUD (yMMUD) vs. 1315 old (≥35 years) Haplo donors (oHaplo) (second comparison). Acute graft-versus-host disease (aGVHD) grades II-IV were significantly lower in the yHaplo vs. oMMUD group (HR = 0.62, p = 0.007). There were no significant differences in chronic GVHD, non-relapse mortality (NRM), relapse incidence, leukemia-free survival, overall survival, and GVHD-free and relapse-free survival. As for the second comparison, more patients in the oHaplo group had de novo AML, 86.6% vs. 81.9% in the yMMUD group (p = 0.044), while myeloablative conditioning was used more frequently in the yMMUD group, 53.3% vs. 46.8% in the oHaplo group (p = 0.049). aGVHD grades II-IV and NRM were significantly lower in the yMMUD vs. oHaplo group (HR = 0.69, p = 0.013 and HR = 0.60, p = 0.022). All other transplant outcomes did not differ. In conclusion, HSCT from young alternative donors (<35 years) results in a lower incidence of grades II-IV aGVHD. In addition, NRM is lower in HSCT from yMMUD compared to HSCT from oHaplo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas / Ciclofosfamida / Donante no Emparentado Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas / Ciclofosfamida / Donante no Emparentado Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Bone Marrow Transplant Asunto de la revista: TRANSPLANTE Año: 2024 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido