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Preclinical evidence of the anti-inflammatory effect and toxicological safety of aryl-cyclohexanone in vivo.
Lubschinski, Tainá Larissa; Pollo, Luiz Antonio Escorteganha; de Oliveira, Paula Giarola Fragoso; Nardino, Luigi Arruda; Mohr, Eduarda Talita Bramorski; da Silva Buss, Ziliani; Sandjo, Louis Pergaud; Biavatti, Maique Weber; Daltoé, Felipe Perozzo; Dalmarco, Eduardo Monguilhott.
Afiliación
  • Lubschinski TL; Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • Pollo LAE; Department of Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • de Oliveira PGF; Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • Nardino LA; Department of Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • Mohr ETB; Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • da Silva Buss Z; Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • Sandjo LP; Department of Chemistry, Center for Physical and Mathematical Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • Biavatti MW; Department of Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • Daltoé FP; Department of Pathology, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
  • Dalmarco EM; Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, Brazil.
Fundam Clin Pharmacol ; 2024 Aug 18.
Article en En | MEDLINE | ID: mdl-39155123
ABSTRACT

BACKGROUND:

Respiratory distress syndrome is a complex inflammatory condition defined by the presence of acute hypoxemia and cellular infiltration with diffuse alveolar injury following a tissue injury, such as acute lung injury. The inflammatory process involved in this pathology is a defense mechanism of the body against infectious agents and/or tissue injuries. However, when the condition is not reversed, it becomes a significant cause of tissue damage, sometimes leading to loss of function of the affected organ. Therefore, it is essential to understand the mechanisms underlying inflammation, as well as the development of new therapeutic agents that reduce inflammatory damage in these cases. Aryl-cyclohexanone derivatives have previously shown significant anti-inflammatory activity linked to an immunomodulatory capacity in vitro and may be good candidates for therapies in which inflammation plays a central role.

METHODS:

Was evaluated the anti-inflammatory capacity of a synthesized molecule aryl-cyclohexanone in the murine model of lipopolysaccharide (LPS)-induced acute lung injury. The assessment of acute oral toxicity follows the Organization for Economic Co-operation and Development (OECD) guideline 423.

RESULTS:

The results demonstrated that the studied molecule protects against LPS-induced inflammation. We observed a decrease in the migration of total and differential leukocytes to the bronchoalveolar lavage fluid (BALF), in addition to a reduction in exudation, myeloperoxidase (MPO) activity, nitric oxide metabolites, and the secretion of pro-inflammatory cytokines (alpha tumor necrosis factors [TNF-α], interleukin-6 [IL-6], interferon-gamma [IFN-γ], and monocyte chemoattractant protein-1 [MCP-1]). Finally, aryl cyclohexanone did not show signs of acute oral toxicity (OECD 423).

CONCLUSIONS:

The results prove our hypothesis that aryl-cyclohexanone is a promising molecule for developing a new, safe anti-inflammatory drug.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Fundam Clin Pharmacol Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Fundam Clin Pharmacol Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido