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Pharmacological Treatment for Dialysis-Related Muscle Cramps: A Systematic Review.
Mantilla-Manosalva, Nidia; Guadarrama, Santiago; Bedoya-Muñoz, Lennis Jazmin; Giraldo-Moreno, Sara; Cuellar-Valencia, Laura; Iriarte-Aristizábal, María Fernanda; León, Marta Ximena; Mendoza-Montenegro, Fernan Alejandro; Correa-Morales, Juan Esteban.
Afiliación
  • Mantilla-Manosalva N; Palliative Care Program, Universidad de La Sabana, Bogotá, Colombia.
  • Guadarrama S; Palliative Care Department, Instituto Nacional de Cancerología, Bogotá, Colombia.
  • Bedoya-Muñoz LJ; Palliative Care Program, Universidad de La Sabana, Bogotá, Colombia.
  • Giraldo-Moreno S; Palliative Care Department, Instituto Nacional de Cancerología, Bogotá, Colombia.
  • Cuellar-Valencia L; Palliative Care Program, Universidad de La Sabana, Bogotá, Colombia.
  • Iriarte-Aristizábal MF; Palliative Care Department, Instituto Nacional de Cancerología, Bogotá, Colombia.
  • León MX; Medicine Department, Universidad CES, Medellín, Colombia.
  • Mendoza-Montenegro FA; Palliative Care Program, Universidad de La Sabana, Bogotá, Colombia.
  • Correa-Morales JE; Palliative Care Department, Instituto Nacional de Cancerología, Bogotá, Colombia.
Semin Dial ; 37(6): 415-423, 2024.
Article en En | MEDLINE | ID: mdl-39155056
ABSTRACT

BACKGROUND:

Patients with end-stage renal disease undergoing dialysis suffer from muscle cramps, a prevalent and burdensome symptom for which there is a paucity of efficient and safe treatments.

AIM:

What is the efficacy and safety of pharmacological interventions for the treatment of dialysis-related muscle cramps?

DESIGN:

A systematic review was conducted in OVID, CINAHL, PubMed, Web of Science, and Central Cochrane databases up to August 25, 2023. DATA SOURCES Experimental studies reporting on a pharmacological intervention for the treatment of dialysis-related muscle cramps were included. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis, and the studies quality was assessed with the RoB2 tool.

RESULTS:

A total of 4660 studies were retrieved, and 13 articles were included. The studies reported on nine

interventions:

vitamin C, vitamin E, vitamin K2, vitamin B7, dextrose solutions, gabapentin, sodium chloride, creatine monohydrate, and L-carnitine. The studies testing L-carnitine and creatine monohydrate were the only ones deemed to have a low risk of bias. Side effects were reported in only two trials, consisting primarily of gastrointestinal discomfort and hyperglycemia. Vitamins C and E are the two most studied interventions that showed positive results in reducing the frequency, severity, and duration of dialysis-related muscle cramps. L-carnitine is a promising intervention that warrants further investigation.

CONCLUSION:

Our review consolidates the existing evidence, elucidating the range of treatments along with their potential benefits and limitations. Future studies should uphold high-quality standards, incorporate patient-reported outcomes, and utilize well-defined, robust samples to improve patient care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Fallo Renal Crónico / Calambre Muscular Límite: Humans Idioma: En Revista: Semin Dial Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diálisis Renal / Fallo Renal Crónico / Calambre Muscular Límite: Humans Idioma: En Revista: Semin Dial Asunto de la revista: NEFROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Estados Unidos