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Anoikis-related genes linked with patient outcome in pancreatic cancer.
Lin, Lizhi; Deng, Jing; Yu, Jiaye; Bauden, Monika; Andersson, Roland; Shen, Xian; Ansari, Daniel; Xue, Xiangyang.
Afiliación
  • Lin L; Department of Surgery, Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden; Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Deng J; Department of Basic Medicine, Wenzhou Medical University, Wenzhou, China.
  • Yu J; Department of Basic Medicine, Wenzhou Medical University, Wenzhou, China.
  • Bauden M; Department of Surgery, Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
  • Andersson R; Department of Surgery, Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden.
  • Shen X; Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Ansari D; Department of Surgery, Clinical Sciences Lund, Lund University, Skåne University Hospital, Lund, Sweden. Electronic address: daniel.ansari@med.lu.se.
  • Xue X; Department of Basic Medicine, Wenzhou Medical University, Wenzhou, China. Electronic address: wzxxy@wmu.edu.cn.
Gene ; 930: 148868, 2024 Dec 20.
Article en En | MEDLINE | ID: mdl-39154969
ABSTRACT
Anoikis is programmed cell death occurring upon cell detachment from the extracellular matrix. Cancer cells need to evade anoikis to be able to metastasize to distant sites. However, the molecular features and prognostic value of anoikis-related genes (ARGs) in pancreatic cancer remain unclear. In this study, we utilized transcriptome data from the TCGA and GSE102238 databases to identify 64 ARGs significantly associated with prognosis. We used the "ConsensusClusterPlus" R package to stratify patients into high and low-risk prognostic subgroups. The KEGG and GSEA analyses revealed that the clusters with poor prognosis were enriched for the ECM receptor interaction pathway, the TP53 signaling pathway, and the galactose metabolism pathway, and that the cell cycle pathway was upregulated. A prognostic model consisting of seven ARGs (SERPINE1, EGF, E2F1, MSLN, RAB27B, ETV7, MST1) was constructed using LASSO regression and when combined with clinicopathological parameters using Cox regression, a prognostic Nomogram was created, which demonstrated high prognostic utility. Among the biomarker candidates, we report ETV7 as a novel, independent prognostic marker in pancreatic cancer. ETV7 was highly expressed in KRAS and TP53 co-occurrent mutant TCGA patients, indicating that it may be regulated by the two major driver genes of pancreatic cancer. Therefore, targeting ETV7 could be a potential focus for future therapeutic studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Anoicis Límite: Female / Humans / Male Idioma: En Revista: Gene Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Anoicis Límite: Female / Humans / Male Idioma: En Revista: Gene Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos