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A comprehensive review on the enantiomeric separation of chiral drugs using metal-organic frameworks.
Abbas, Anees; Ahmad, Muhammad Sheraz; Cheng, Yu-Hsiang; AlFaify, S; Choi, Soohoon; Irfan, Rana Muhammad; Numan, Arshid; Khalid, Mohammad.
Afiliación
  • Abbas A; Department of Chemistry, University of Mianwali, Mianwali, Punjab, 42200, Pakistan; Graphite Technology, No. 9 Sinosteel Avenue 313100 Changxing, Zhejiang, China.
  • Ahmad MS; Department of Chemistry, University of Mianwali, Mianwali, Punjab, 42200, Pakistan; Center for Environmental Sustainability and Human Health, Ming Chi University of Technology, New Taipei City, 24301, Taiwan. Electronic address: chemist019@gmail.com.
  • Cheng YH; Center for Environmental Sustainability and Human Health, Ming Chi University of Technology, New Taipei City, 24301, Taiwan; Department of Safety, Health and Environmental Engineering, Ming Chi University of Technology, New Taipei City, 24301, Taiwan. Electronic address: yhcheng@mail.mcut.edu.tw.
  • AlFaify S; Advanced Functional Materials and Optoelectronics Laboratory (AFMOL), Department of Physics, College of Science, King Khalid University, Abha, 61413, P.O. Box 9004, Saudi Arabia.
  • Choi S; Department of Environmental Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, 34134, South Korea.
  • Irfan RM; Department of Pharmacy, Shanghai Jiaotong University, Shanghai, China.
  • Numan A; Sunway Centre for Electrochemical Energy and Sustainable Technology (SCEEST), School of Engineering and Technology, Sunway University, No. 5, Jalan Universiti, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia; Department of Applied Physics, Saveetha School of Engineering, Saveetha University (SI
  • Khalid M; Materials and Manufacturing Research Group, James Watt School of Engineering, University of Glasgow, Glasgow, G128QQ, UK; University Centre for Research and Development, Chandigarh University, Mohali, Punjab, 140413, India. Electronic address: mohammad.khalid@glasgow.ac.uk.
Chemosphere ; 364: 143083, 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-39154761
ABSTRACT
Chiral drugs play an important role in modern medicine, but obtaining pure enantiomers from racemic mixtures can pose challenges. When a drug is chiral, only one enantiomer (eutomer) typically exhibits the desired pharmacological activity, while the other (distomer) may be biologically inactive or even toxic. Racemic drug formulations introduce additional health risks, as the body must still process the inactive or detrimental enantiomer. Some distomers have also been linked to teratogenic effects and unwanted side effects. Therefore, developing efficient and scalable methods for separating chiral drugs into their pure enantiomers is critically important for improving patient safety and outcomes. Metal-organic frameworks (MOFs) show promise as novel materials for chiral separation due to their highly tunable structures and interactions. This review summarizes recent advancements in using MOFs for chromatographic and spectroscopic resolution of drug enantiomers. Both the opportunities and limitations of MOF-based separation techniques are discussed. A thorough understanding of these methods could aid the continued development of pure enantiomer formulations and help reduce health risks posed by racemic drug mixtures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemosphere Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chemosphere Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido