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Population Pharmacokinetic of Vancomycin Administered by Continuous Infusion in Critically Ill Patients.
Ben Romdhane, Haifa; Woillard, Jean Baptiste; Ben Fadhel, Najah; Chadli, Zohra; Chaabane, Amel; Boughattas, Naceur; Ben Fredj, Nadia; Aouam, Karim.
Afiliación
  • Ben Romdhane H; Department of Pharmacology, EPS Fattouma Bourguiba, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
  • Woillard JB; Department of Pharmacology and Toxicology, Centre Hospitalier Universitaire à Limoges, Limoges, France.
  • Ben Fadhel N; Department of Pharmacology, EPS Fattouma Bourguiba, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
  • Chadli Z; Department of Pharmacology, EPS Fattouma Bourguiba, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
  • Chaabane A; Department of Pharmacology, EPS Fattouma Bourguiba, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
  • Boughattas N; Department of Pharmacology, EPS Fattouma Bourguiba, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
  • Ben Fredj N; Department of Pharmacology, EPS Fattouma Bourguiba, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
  • Aouam K; Department of Pharmacology, EPS Fattouma Bourguiba, Faculty of Medicine, University of Monastir, Monastir, Tunisia.
Pharmacology ; : 1-12, 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-39154639
ABSTRACT

INTRODUCTION:

Administration of vancomycin dose by continuous infusion (CI) according to population pharmacokinetic (Pop Pk) models is highly recommended in critically ill patients who exhibit pathophysiological changes.

OBJECTIVE:

The objective of this study was to develop and validate a Pop Pk model of vancomycin administered by CI in critically ill patients with normal and impaired renal functions.

METHODS:

The Pop Pk study was performed using a nonparametric approach (Pmetrics*). The influence of covariates (gender, age, weight, height, and creatinine clearance [Cr-Cl]) was tested on the model's Pk parameters. The performance of the final model was assessed using an external dataset.

RESULTS:

A one-compartment model (volume of distribution [Vd], elimination from compartment [Ke]) was found to show a good prediction performance. The influence of covariates has shown that age and Cr-Cl affected significantly Vd and Ke, respectively. The distribution of simulated vancomycin clearance (CLv) according to different renal function levels showed a negative correlation between CLv and the severity of the renal impairment. The internal validation of the final model showed that the plot of individual-predicted concentration versus observed concentration resulted in r2 = 0.86 in the final model. The external validation of the final model showed an acceptable predictive performance.

CONCLUSION:

We developed a Pop Pk model for vancomycin administered by CI in critically ill patients. A significant impact of Cr-Cl and different stages of renal failure on CLv has been demonstrated. The establishment of an individualized proposal dose based on this model may be helpful to achieve the target range which is critical in optimizing the efficacy and safety of this antibiotic.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmacology Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Pharmacology Año: 2024 Tipo del documento: Article País de afiliación: Túnez Pais de publicación: Suiza