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The role of ventral hippocampal-medial prefrontal glutamatergic pathway on the non-affected side in post-stroke cognitive impairment.
Zhao, Yuehan; Peng, Yuan; Pan, Yao; Lv, Yichen; Zhou, Hongyu; Wu, Jiahao; Gong, Jianwei; Wang, Xin.
Afiliación
  • Zhao Y; School of Special Education and Rehabilitation, Binzhou Medical University, Yantai 264003, Shandong, China; Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu, China. Electronic address: Aa19861802747@163.com.
  • Peng Y; Department of Rehabilitation Medicine, Guangzhou First People's Hospital, Second Affiliated Hospital of South China University of Technology, Guangzhou 510180, Guangdong, China. Electronic address: eyyuanpeng@scut.edu.cn.
  • Pan Y; School of Special Education and Rehabilitation, Binzhou Medical University, Yantai 264003, Shandong, China; Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu, China. Electronic address: panyao5678@163.com.
  • Lv Y; Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu, China. Electronic address: lyc_job123@163.com.
  • Zhou H; Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu, China. Electronic address: 785456129@qq.com.
  • Wu J; Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu, China. Electronic address: 978769291@qq.com.
  • Gong J; School of Special Education and Rehabilitation, Binzhou Medical University, Yantai 264003, Shandong, China. Electronic address: jwgongfzh@163.com.
  • Wang X; Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, Jiangsu, China; Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital, Yangzhou 225001, Jiangsu, China. Electronic address: wx000805qm@yeah.net.
Brain Res ; 1845: 149168, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39153591
ABSTRACT
Elucidate the pathogenesis mechanism of post-stroke cognitive impairment (PSCI) can help to develop precision interventions. In this study, we established a mouse model of PSCI using the photochemical method, and behavioral tests including Y-maze and Novel object recognition task for accessing cognitive impairment were observed at week 2 post-stroke. Besides, synaptic plasticity, theta nerve oscillatory and the activity of glutamatergic neurons related to the ventral hippocampal-medial prefrontal glutamatergic neural pathway in the non-affected hemisphere (contralateral hemisphere to the lesion site) were observed. The result indicated the cognitive function declined at week 2 post-stroke. Synaptic plasticity, theta nerve oscillatory synchronization and the activity of glutamatergic neurons of the ventral hippocampal-medial prefrontal glutamatergic neural pathway in the non-affected hemisphere was down-regulated in the PSCI group compared to those of the SHAM group. Therefore, we concluded that the declined function of the ventral hippocampal-medial prefrontal glutamatergic pathway in the non-affected hemisphere is a biomarker in the occurrence of cognitive dysfunction after stroke.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Brain Res Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos