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Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity.
Tian, Guilian; Bartas, Katrina; Hui, May; Chen, Lingxuan; Vasquez, Jose J; Azouz, Ghalia; Derdeyn, Pieter; Manville, Rían W; Ho, Erick L; Fang, Amanda S; Li, Yuan; Tyler, Isabella; Setola, Vincent; Aoto, Jason; Abbott, Geoffrey W; Beier, Kevin T.
Afiliación
  • Tian G; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Bartas K; Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA, USA.
  • Hui M; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Chen L; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Vasquez JJ; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Azouz G; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Derdeyn P; Program in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA, USA.
  • Manville RW; Bioelectricity Laboratory, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Ho EL; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Fang AS; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Li Y; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Tyler I; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Setola V; Department of Neuroscience, West Virginia University, Morgantown, WV, USA; Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA.
  • Aoto J; University of Colorado Anschutz School of Medicine, Department of Pharmacology, Aurora, CO, USA.
  • Abbott GW; Bioelectricity Laboratory, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA.
  • Beier KT; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA; Department of Neurobiology an
Neuron ; 2024 Aug 14.
Article en En | MEDLINE | ID: mdl-39153478
ABSTRACT
The globus pallidus externus (GPe) is a central component of the basal ganglia circuit that acts as a gatekeeper of cocaine-induced behavioral plasticity. However, the molecular and circuit mechanisms underlying this function are unknown. Here, we show that GPe parvalbumin-positive (GPePV) cells mediate cocaine responses by selectively modulating ventral tegmental area dopamine (VTADA) cells projecting to the dorsomedial striatum (DMS). Interestingly, GPePV cell activity in cocaine-naive mice is correlated with behavioral responses following cocaine, effectively predicting cocaine sensitivity. Expression of the voltage-gated potassium channels KCNQ3 and KCNQ5 that control intrinsic cellular excitability following cocaine was downregulated, contributing to the elevation in GPePV cell excitability. Acutely activating channels containing KCNQ3 and/or KCNQ5 using the small molecule carnosic acid, a key psychoactive component of Salvia rosmarinus (rosemary) extract, reduced GPePV cell excitability and impaired cocaine reward, sensitization, and volitional cocaine intake, indicating its therapeutic potential to counteract psychostimulant use disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos