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Towards personalized and rational use of immunoglobulins amid expanding indications and shortages.
Goubran, Hadi; Ragab, Gaafar; Seghatchian, Jerard; Burnouf, Thierry.
Afiliación
  • Goubran H; Saskatoon Cancer Centre and College of Medicine, University of Saskatchewan, Saskatchewan, Canada.
  • Ragab G; Rheumatology and Immunology Unit, Internal Medicine Department, Cairo University, Egypt.
  • Seghatchian J; International Consultancy in Blood Components Quality/Safety Improvement, Audit/Inspection and DDR Strategies, London, UK.
  • Burnouf T; Graduate Institute of Biological Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan. Electronic address: th
Transfus Apher Sci ; 63(5): 103987, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39153330
ABSTRACT
The development of intravenous IgG (IVIG) formulations in the 1970s enabled expanded use for treating primary antibody deficiency syndromes and autoimmune conditions. Recent advancements include the use of IVIG in secondary immune deficiencies related to hematologic malignancies and stem cell transplantation, along with the newly emerging prophylactic applications following chimeric antigen receptor T-cell (CAR-T) therapies. Novel therapeutic areas such as bispecific antibodies (BsAbs) for lymphoma and myeloma have increased the use of IgG, given the associated risks of infections. Today, the concept of a rational personalized clinical use of IgG in the context of evolving clinical indications in high-income countries (HIC) is emerging, as unmet challenges in line with managing shortages due to increasing demands globally. The current work aims to review and link the indications for IgG to their characteristics and formulations, their dose, route and frequency of administrations and duration of therapy to meet the needs of individual patients. It will also explore the means to rationalize and monitor IgG use in HIC in the time of shortage, while explaining pragmatic strategies to improve supply and use in low- and middle-income countries (LMIC).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicina de Precisión Límite: Humans Idioma: En Revista: Transfus Apher Sci Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicina de Precisión Límite: Humans Idioma: En Revista: Transfus Apher Sci Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido