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Prognostic value of the electrocardiogram in patients with bicuspid aortic valve disease.
Hendriks, Paul M; Keuning, Zoë A; Kors, Jan A; van den Hoven, Allard T; Geenen, Laurie W; Eindhoven, Jannet A; Baggen, Vivan J M; Cuypers, Judith A A E; Kauling, Robert M; Roos-Hesselink, Jolien W; van den Bosch, Annemien E.
Afiliación
  • Hendriks PM; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Keuning ZA; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Kors JA; Department of Medical Informatics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • van den Hoven AT; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Geenen LW; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Eindhoven JA; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Baggen VJM; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Cuypers JAAE; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Kauling RM; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Roos-Hesselink JW; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands; ERN-GUARD-Heart: European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Rotterdam, the Netherlands.
  • van den Bosch AE; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands; ERN-GUARD-Heart: European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Rotterdam, the Netherlands. Electronic address: a.e.vandenbosch@erasmusmc.nl.
J Electrocardiol ; 86: 153760, 2024.
Article en En | MEDLINE | ID: mdl-39153288
ABSTRACT

BACKGROUND:

Identifying bicuspid aortic valve (BAV) patients at risk for cardiac events remains challenging and the role of the electrocardiogram (ECG) has not yet been described. Therefore, this study aims to describe ECG parameters in BAV patients, and investigate their prognostic value.

METHODS:

In this single-center prospective study patients with BAV without a prior aortic valve replacement (AVR) were included. Transthoracic echocardiogram and 12­lead resting-ECG were obtained. Associations between ECG parameters and the composite endpoint of all-cause mortality and AVR were assessed using Cox-proportional hazard analysis.

RESULTS:

120 patients with BAV were included (median age 30 years, 61% male). Median aortic jet velocity was 2.4 m/s [IQR 1.7-3.4] and 5 patients (4%) had severe aortic regurgitation. All patients were in sinus rhythm. Any ECG abnormality was present in 57 patients (48%). Median PR-interval was 156 [IQR 138-170] msec. A deviating QRS axis was found in 17 patients (14%) and Cornell criteria for LVH were fulfilled in 20 patients (17%). Repolarization abnormalities were present in 12 patients (10%). Median follow-up duration was 7.0 [6.3-9.8] years, during which 23 patients underwent AVR and 2 patients died. After adjusting for age, a longer PR-interval was associated with worse intervention-free survival (HR 1.02, 95% CI 1.01-1.04).

CONCLUSION:

Almost half of the patients with BAV had abnormalities on their ECG. Moreover, the PR-interval may be an interesting prognostic marker for intervention-free survival in BAV patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Válvula Aórtica / Electrocardiografía / Enfermedad de la Válvula Aórtica Bicúspide Límite: Adult / Female / Humans / Male Idioma: En Revista: J Electrocardiol Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Válvula Aórtica / Electrocardiografía / Enfermedad de la Válvula Aórtica Bicúspide Límite: Adult / Female / Humans / Male Idioma: En Revista: J Electrocardiol Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos