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Remimazolam anesthesia in pediatric patients undergoing cardiac catheterization for congenital heart disease: a retrospective observational study.
Hosokawa, Maiko; Takahashi, Yurie; Ueno, Takahiro; Oe, Katsunori; Masui, Kenichi.
Afiliación
  • Hosokawa M; Department of Anesthesiology, Showa University School of Medicine, Tokyo, Japan.
  • Takahashi Y; Department of Anesthesiology, Showa University School of Medicine, Tokyo, Japan.
  • Ueno T; Department of Anesthesiology, Showa University School of Medicine, Tokyo, Japan.
  • Oe K; Department of Anesthesiology, Showa University School of Medicine, Tokyo, Japan.
  • Masui K; Department of Anesthesiology, Yokohama City University School of Medicine, Fukuura 3-9, Kanazawa-Ku, Yokohama, 236-0004, Japan. kenichi@masuinet.com.
J Anesth ; 2024 Aug 17.
Article en En | MEDLINE | ID: mdl-39153037
ABSTRACT

BACKGROUND:

Benzodiazepines are used in pediatric patients with congenital heart disease (CHD) because of their mild hemodynamic depressant effects. A novel short-acting benzodiazepine, remimazolam, is expected to be suitable for these patients. We examined the characteristics of remimazolam anesthesia in pediatric patients with CHD undergoing cardiac catheterization.

METHODS:

This single-center retrospective study included pediatric patients undergoing cardiac catheterization for CHD. The primary outcome was the remimazolam dose for loss of consciousness. Secondary outcomes included the mean maintenance remimazolam dose, recovery time from anesthesia, predicted remimazolam concentration at emergence, decrease in blood pressure and heart rate, vasopressor administration during anesthesia, electroencephalogram index (bispectral index BIS or patient state index PSI), and life-threatening adverse events.

RESULTS:

Thirty-nine patients, aged 2 months to 16 years, were included. Thirty-three patients received a median [interquartile] midazolam dose of 0.10 [0.10-0.10] mg.kg-1 in the pre-anesthesia room. The remimazolam dose for loss of consciousness was 0.34 [0.26-0.45] mg.kg-1. The mean maintenance dose was 1.0 [0.8-1.4] mg.kg-1.h-1. The recovery time was 15 [12-17] min. The predicted remimazolam concentration at emergence was 0.4-1.2 µg.ml-1 in 3-6-year-old patients. Blood pressure and heart rate decreased by 30% in 15 and 6 patients, respectively. Vasopressors were administered as a bolus in 8 patients. The BIS or PSI did not fall ≤ 60 or ≤ 50, respectively, in 51% of patients before tracheal intubation. No life-threatening adverse events were reported.

CONCLUSIONS:

Remimazolam is a good alternative anesthetic agent for pediatric patients undergoing cardiac catheterization for CHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Anesth Asunto de la revista: ANESTESIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Anesth Asunto de la revista: ANESTESIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón