Your browser doesn't support javascript.
loading
Risk factors associated with blood transfusion in liver transplantation.
Pérez, Lourdes; Sabate, Antoni; Gutierrez, Rosa; Caballero, Marta; Pujol, Roger; Llaurado, Sandra; Peñafiel, Judith; Hereu, Pilar; Blasi, Annabel.
Afiliación
  • Pérez L; Department of Anesthesiology, University Hospital of Bellvitge, University of Barcelona Health Campus, IDIBELL, Feixa Llarga S/N. Hospitalet., 08 907, Barcelona, Spain.
  • Sabate A; Department of Anesthesiology, University Hospital of Bellvitge, University of Barcelona Health Campus, IDIBELL, Feixa Llarga S/N. Hospitalet., 08 907, Barcelona, Spain. asabatep@bellvitgehospital.cat.
  • Gutierrez R; Department of Anesthesiology, University Hospital of Cruces, Bilbao, Spain.
  • Caballero M; Department of Anesthesiology, University Hospital of Bellvitge, University of Barcelona Health Campus, IDIBELL, Feixa Llarga S/N. Hospitalet., 08 907, Barcelona, Spain.
  • Pujol R; Department of Anesthesiology, Clinic Hospital, University of Barcelona Health Barcelona, Spain Campus, IDIBAPS, Barcelona, Spain.
  • Llaurado S; Department of Anesthesiology, University Hospital of Bellvitge, University of Barcelona Health Campus, IDIBELL, Feixa Llarga S/N. Hospitalet., 08 907, Barcelona, Spain.
  • Peñafiel J; UICEC, Biostatistics Unit (UBiDi), University of Barcelona Health Campus. IDIBELL, Barcelona, Spain.
  • Hereu P; UICEC, Biostatistics Unit (UBiDi), University of Barcelona Health Campus. IDIBELL, Barcelona, Spain.
  • Blasi A; Department of Anesthesiology, Clinic Hospital, University of Barcelona Health Barcelona, Spain Campus, IDIBAPS, Barcelona, Spain.
Sci Rep ; 14(1): 19022, 2024 08 16.
Article en En | MEDLINE | ID: mdl-39152310
ABSTRACT
To explore preoperative and operative risk factors for red blood cell (RBC) transfusion requirements during liver transplantation (LT) and up to 24 h afterwards. We evaluated the associations between risk factors and units of RBC transfused in 176 LT patients using a log-binomial regression model. Relative risk was adjusted for age, sex, and the model for end-stage liver disease score (MELD) (adjustment 1) and baseline hemoglobin concentration (adjustment 2). Forty-six patients (26.14%) did not receive transfusion. Grafts from cardiac-death donors were used in 32.61% and 31.54% of non-transfused and transfused patients, respectively. The transfused group required more reoperation for bleeding (P = 0.035), longer mechanical ventilation after LT (P < 0.001), and longer ICU length of stay (P < 0.001). MELD and hemoglobin concentrations determined RBC requirements. For each unit of increase in the MELD score, 2% more RBC units were transfused, and non-transfusion was 0.83-fold less likely. For each 10-g/L higher hemoglobin concentration at baseline, 16% less RBC transfused, and non-transfusion was 1.95-fold more likely. Ascites was associated with 26% more RBC transfusions. With an increase of 2 mm from the baseline in the A10FIBTEM measurement of maximum clot firmness, non-transfusion was 1.14-fold more likely. A 10-min longer cold ischemia time was associated with 1% more RBC units transfused, and the presence of post-reperfusion syndrome with 45% more RBC units. We conclude that preoperative correction of anemia should be included in LT. An intervention to prevent severe hypotension and fibrinolysis during graft reperfusion should be explored.Trial register European Clinical Trials Database (EudraCT 2018-002,510-13) and ClinicalTrials.gov (NCT01539057).
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Hígado Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Hígado Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido