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Neurocognitive effects of 3 mA prefrontal electrical stimulation in schizophrenia: A randomized sham-controlled tDCS-fMRI study protocol.
Hallajian, Amir-Homayun; Sharifi, Kiomars; Rostami, Reza; Saeed, Fahimeh; Mokarian Rajabi, Shirin; Zangenehnia, Negin; Amini, Zahra; Askari, Zahra; Vila-Rodriguez, Fidel; Salehinejad, Mohammad Ali.
Afiliación
  • Hallajian AH; Department of Psychology, University of Tehran, Tehran, Iran.
  • Sharifi K; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
  • Rostami R; Department of Psychology, University of Tehran, Tehran, Iran.
  • Saeed F; Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
  • Mokarian Rajabi S; Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
  • Zangenehnia N; Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
  • Amini Z; Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
  • Askari Z; School of Biomedical Engineering, University of British Columbia, Vancouver, Canada.
  • Vila-Rodriguez F; Department of Psychiatry, University of British Columbia, Vancouver, Canada.
  • Salehinejad MA; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
PLoS One ; 19(8): e0306422, 2024.
Article en En | MEDLINE | ID: mdl-39150917
ABSTRACT

BACKGROUND:

Schizophrenia (SCZ) is characterized by cognitive deficits that are linked to prefrontal cortex dysfunction. While transcranial direct current stimulation (tDCS) shows promise for improving cognition, the effects of intensified 3mA tDCS protocols on brain physiology are unknown. This project aims to elucidate the neurophysiological and cognitive effects of an intensified prefrontal tDCS protocol in SCZ.

METHODS:

The study is designed as a randomized, double-blind, 2-arm parallel-group, sham-controlled, trial. Forty-eight participants with SCZ and cognitive impairment (measured via a set of executive functions tests) will be randomly allocated to receive either a single session of active (n = 24) or sham (n = 24) tDCS (20-min, 3-mA). The anodal and cathodal electrodes are positioned over the left and right DLPFC respectively. The stimulation occurs concurrently with the working memory task, which is initiated precisely 5 minutes after the onset of tDCS. Structural and resting-state (rs-fMRI) scans are conducted immediately before and after both active and sham tDCS using a 3 Tesla scanner (Siemens Prisma model) equipped with a 64-channel head coil. The primary outcome will be changes in brain activation (measures vis BOLD response) and working memory performance (accuracy, reaction time).

DISCUSSION:

The results of this study are helpful in optimizing tDCS protocols in SCZ and inform us of neurocognitive mechanisms underlying 3 mA stimulation. This study will additionally provide initial safety and efficacy data on a 3 mA tDCS protocol to support larger clinical trials. Positive results could lead to rapid and broader testing of a promising tool for debilitating symptoms that affect the majority of patients with SCZ. The results will be made available through publications in peer-reviewed journals and presentations at national and international conferences.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Imagen por Resonancia Magnética / Corteza Prefrontal / Cognición / Estimulación Transcraneal de Corriente Directa Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Imagen por Resonancia Magnética / Corteza Prefrontal / Cognición / Estimulación Transcraneal de Corriente Directa Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos