Your browser doesn't support javascript.
loading
Translation efficiency covariation across cell types is a conserved organizing principle of mammalian transcriptomes.
Liu, Yue; Hoskins, Ian; Geng, Michael; Zhao, Qiuxia; Chacko, Jonathan; Qi, Kangsheng; Persyn, Logan; Wang, Jun; Zheng, Dinghai; Zhong, Yochen; Rao, Shilpa; Park, Dayea; Cenik, Elif Sarinay; Agarwal, Vikram; Ozadam, Hakan; Cenik, Can.
Afiliación
  • Liu Y; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Hoskins I; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Geng M; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Zhao Q; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Chacko J; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Qi K; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Persyn L; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Wang J; mRNA Center of Excellence, Sanofi, Waltham, MA 02451, USA.
  • Zheng D; mRNA Center of Excellence, Sanofi, Waltham, MA 02451, USA.
  • Zhong Y; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Rao S; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Park D; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Cenik ES; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Agarwal V; mRNA Center of Excellence, Sanofi, Waltham, MA 02451, USA.
  • Ozadam H; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.
  • Cenik C; Present address: Sail Biomedicines, Cambridge, MA, 02141, USA.
bioRxiv ; 2024 Aug 11.
Article en En | MEDLINE | ID: mdl-39149359
ABSTRACT
Characterization of shared patterns of RNA expression between genes across conditions has led to the discovery of regulatory networks and novel biological functions. However, it is unclear if such coordination extends to translation, a critical step in gene expression. Here, we uniformly analyzed 3,819 ribosome profiling datasets from 117 human and 94 mouse tissues and cell lines. We introduce the concept of Translation Efficiency Covariation (TEC), identifying coordinated translation patterns across cell types. We nominate potential mechanisms driving shared patterns of translation regulation. TEC is conserved across human and mouse cells and helps uncover gene functions. Moreover, our observations indicate that proteins that physically interact are highly enriched for positive covariation at both translational and transcriptional levels. Our findings establish translational covariation as a conserved organizing principle of mammalian transcriptomes.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos