Your browser doesn't support javascript.
loading
Role of pyridoxine and oxidative stress in asthenozoospermia.
Bdeir, Roba; Aljabali, Shefa' Muneer; Banihani, Saleem Ali.
Afiliación
  • Bdeir R; Department of Allied Health Sciences, Faculty of Nursing, Al-Balqa Applied University, As-salt, Jordan.
  • Aljabali SM; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jadara University, Irbid, Jordan.
  • Banihani SA; Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Jadara University, Irbid, Jordan.
Heliyon ; 10(14): e34799, 2024 Jul 30.
Article en En | MEDLINE | ID: mdl-39148988
ABSTRACT

Purpose:

Infertility is a worldwide concern, and recent research indicates that vitamin B6 deficiency may play a role in male infertility, primarily by inducing hyperhomocysteinemia and oxidative stress. These processes can have a detrimental effect on semen quality, ultimately affecting male fertility. Here, we aim to evaluate the biochemical status of pyridoxine (vitamin B6) in relation to total glutathione and total antioxidant capacity. Materials and

methods:

A case control study samples were collected of asthenozoospermic (n = 63) and normospermic (n = 43) cases, with average men age 30.35 ± 7.03 years old. Semen plasma specimens representing both fertile and sub-fertile men visiting two different secondary care health institute in Irbid province, Jordan. All samples were assessed according to WHO guidelines (2021) and by using spectrophotometry to evaluate the semen plasma levels of vitamin B6, glutathione (GSH) and total antioxidant capacity (TAC).

Results:

Our main finding is there is significant positive correlations between the seminal plasma concentration of GSH (p < 0.0001) and TAC (p < 0.0073) are significantly correlated with vitamin B6 deficiency in asthenozoospermia group in comparison to normozoospermia cases. A significant decrease (p < 0.0001) the levels of vitamin B6 in men with asthenozoospermia compared to normozoospermic men (control) with an approximate 80 % percent reduction in the mean levels between groups.

Conclusions:

These findings suggest that pyridoxine deficiency may very well alter the GSH system, in so doing affecting the antioxidant defense mechanism against reactive oxygen species to sperm, impacting sperm development and maturation. leading to asthenozoospermia.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: Jordania Pais de publicación: Reino Unido