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Natural product anticipation via chemical synthesis: Discovery of two new securinega alkaloids.
Kim, Minji; Park, Sangbin; Kang, Gyumin; Jang, Yoon Seo; Kim, Ki Hyun; Han, Sunkyu; Kim, Chung Sub.
Afiliación
  • Kim M; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Park S; Department Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Kang G; Department Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Jang YS; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Kim KH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
  • Han S; Department Chemistry, Korea Advanced Institute of Science & Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Kim CS; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Republic of Korea.
iScience ; 27(8): 110495, 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-39148712
ABSTRACT
The isolation of a natural product conventionally precedes its chemical synthesis. Often, the isolation and structure determination of a natural product present in minute quantities in its natural source pose formidable challenges, akin to finding "a needle in a haystack." On the other hand, leveraging plausible biosynthetic insights and biomimetic synthetic expertise would allow for the prior synthesis of presumed natural products, followed by their verification in natural sources. In this study, we unveil two novel securinega alkaloids, securingines H and I, employing the natural product anticipation through synthesis approach. Structural analysis of securingines H and I suggests that they are biosynthetic derivatives of secu'amamine E and securinol A, respectively. We posit that this "synthesis first" strategy represents a valuable approach to the discovery of new natural products.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: IScience Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos