Your browser doesn't support javascript.
loading
Photobiomodulation efficacy in age-related macular degeneration: a systematic review and meta-analysis of randomized clinical trials.
Rassi, Tiago N O; Barbosa, Lucas M; Pereira, Sacha; Novais, Eduardo A; Penha, Fernando; Roisman, Luiz; Maia, Mauricio.
Afiliación
  • Rassi TNO; Department of Ophthalmology, Banco de Olhos Foundation of Goiás, Goiânia, Brazil.
  • Barbosa LM; Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
  • Pereira S; Department of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil. lucasmend78@gmail.com.
  • Novais EA; Department of Medicine, Faculty of Medical Science of Paraíba, João Pessoa, Brazil.
  • Penha F; Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
  • Roisman L; Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.
  • Maia M; Department of Ophthalmology, Regional University of Blumenau, Blumenau, Brazil.
Int J Retina Vitreous ; 10(1): 54, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39148091
ABSTRACT

BACKGROUND:

Age-related macular degeneration (AMD) is a leading cause of vision loss. Photobiomodulation (PBM) offers a controversial approach for managing dry AMD, aiming to halt or reverse progression through mitochondrial activity modulation. However, the efficacy and clinical relevance of PBM as a potential approach for managing dry AMD remain debated.

METHODS:

We systematically searched PubMed, Embase, and Cochrane databases for randomized controlled trials (RCTs) comparing PBM versus a sham in patients with dry AMD. We performed trial sequential analysis (TSA) and minimal clinically important difference (MCID) calculations to assess statistical and clinical significance applying a random-effects model with 95% confidence intervals (CI).

RESULTS:

We included three RCTs comprising 247 eyes. The pooled analysis showed that PBM significant improved BCVA (MD 1.76 letters; 95% CI 0.04 to 3.48) and drusen volume (MD -0.12 mm³; 95% CI -0.22 to -0.02) as compared with a sham control. However, the TSA indicated that the current sample sizes were insufficient for reliable conclusions. No significant differences were observed in GA area. The MCID analysis suggested that the statistically significant results did not translate into clinically significant benefits. In the quality assessment, all studies were deemed to have a high risk of bias.

CONCLUSION:

This meta-analysis points limitations in the current evidence base for PBM in dry AMD treatment, with issues around small sample sizes. Statistically significant improvements do not translate into clinical benefits. The research underscores need for larger RCTs to validate PBM's therapeutic potential for dry AMD.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Retina Vitreous Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Retina Vitreous Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido