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The Rise of Patients Declining Rectal Cancer Surgery in the Era of Total Neoadjuvant Therapy.
Hilty Chu, Bailey K; Loria, Anthony; Dhimal, Totadri; Li, Yue; Colugnati, Fernando; Yousefi Nooraie, Reza; Cupertino, Paula; Aquina, Christopher T; Ramsdale, Erika E; Fleming, Fergal J.
Afiliación
  • Hilty Chu BK; Surgical Health Outcomes and Reaching for Equity (SHORE), Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA. Bailey_HiltyChu@urmc.rochester.edu.
  • Loria A; Surgical Health Outcomes and Reaching for Equity (SHORE), Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
  • Dhimal T; Surgical Health Outcomes and Reaching for Equity (SHORE), Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
  • Li Y; Surgical Health Outcomes and Reaching for Equity (SHORE), Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
  • Colugnati F; Department of Public Health Sciences, University of Rochester, Rochester, NY, USA.
  • Yousefi Nooraie R; School of Medicine, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.
  • Cupertino P; Department of Public Health Sciences, University of Rochester, Rochester, NY, USA.
  • Aquina CT; Surgical Health Outcomes and Reaching for Equity (SHORE), Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
  • Ramsdale EE; Departments of Colorectal Surgery and Surgical Oncology, Advent Health Orlando, Orlando, FL, USA.
  • Fleming FJ; James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA.
Ann Surg Oncol ; 31(12): 7798-7806, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39148007
ABSTRACT

BACKGROUND:

The treatment landscape for rectal cancer is rapidly evolving, particularly with the increasing use of neoadjuvant therapies. Still, up to 50% of patients with stage II-III disease require surgical resection post-neoadjuvant therapy to achieve the best oncologic outcomes. Many patients, however, hope to avoid surgery. This study aimed to assess trends and factors associated with declining recommended oncologic resection after systemic therapy nationally and in our institution. PATIENTS AND

METHODS:

This is a retrospective analysis using the National Cancer Database from 2009 to 2021 and an institutional cohort at an academic center between 2009 and 2022 including adults with stage I-III rectal adenocarcinoma who underwent neoadjuvant therapy and were suitable for surgery.

RESULTS:

Of 96,997 patients nationally, the rate of declining surgery increased from 2.3% in 2009 to 6.3% in 2021, a trend mirrored in our institutional cohort of 365 patients (0% in 2009/2010 to approximately 6-12% in 2021/2022). Locally, patients who declined surgery had higher rates of tobacco use, temporary loss to follow-up during therapy, and a more robust, albeit incomplete, tumor response to neoadjuvant therapy compared with controls who underwent surgery. Despite a stoma being the most cited reason for declining surgery, 30.4% of patients who declined oncologic resection died with a stoma.

CONCLUSIONS:

Our findings underscore a notable trend of patients declining oncologic resections following neoadjuvant therapy for rectal cancer. By shedding light on the outcomes of patients who opt against surgery, we address a critical gap in the literature essential for informing patients about potential risks.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Adenocarcinoma / Terapia Neoadyuvante Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Adenocarcinoma / Terapia Neoadyuvante Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos