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Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation.
Li, Li; Xu, Ziqian; Ni, Haoran; Meng, Yesong; Xu, Yongzhuang; Xu, Hao; Zheng, Yuyang; Zhang, Yi; Xue, Geng; Shang, Yan.
Afiliación
  • Li L; Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China. Electronic address: respirlilee@163.com.
  • Xu Z; Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China.
  • Ni H; Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China.
  • Meng Y; Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China.
  • Xu Y; Department of General Practice, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China.
  • Xu H; Department of General Practice, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China.
  • Zheng Y; Department of General Practice, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China.
  • Zhang Y; Department of General Practice, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China. Electronic address: yizhang_smmu@163.com.
  • Xue G; Department of Medical Genetics, College of Basic Medical Sciences, Naval Military Medical University (Second Military Medical University), Shanghai 200433, China. Electronic address: xg_smmu@hotmail.com.
  • Shang Y; Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Military Medical University (Second Military Medical University), Shanghai, 200433, China; Department of General Practice, Shanghai Changhai Hospital, The First Affiliated Hospita
Free Radic Biol Med ; 224: 50-61, 2024 Aug 13.
Article en En | MEDLINE | ID: mdl-39147072
ABSTRACT
Hydrogen-rich water (HRW) is a beverage containing a high concentration of hydrogen that has been researched for its antioxidant, anti-apoptotic, and anti-inflammatory properties in asthma. This study investigates the potential therapeutic impact of HRW on the gut-lung axis. Using 16S rRNA and serum metabolomics, we examined changes in gut microbiota and serum metabolites in asthmatic mice after HRW intervention, followed by validation experiments. The findings revealed that HRW influenced gut microbiota by increasing Ligilactobacillus and Bifidobacterium abundance and enhancing the presence of indole-3-acetic acid (IAA), a microbially derived serum metabolite. Both in vivo and in vitro experiments showed that HRW's protective effects against airway inflammation in asthmatic mice may be linked to the gut microbiota, with IAA potentially playing a role in reducing asthmatic airway inflammation through the aryl hydrocarbon receptors (AhR) signaling pathway. In summary, HRW can modify gut microbiota, increase Bifidobacterium abundance, elevate microbial-derived IAA levels, and activate AhR, which could potentially alleviate inflammation in asthma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos