Bone and entheseal targets for growth factors in diffuse idiopathic skeletal hyperostosis.
Semin Arthritis Rheum
; 68: 152532, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39146917
ABSTRACT
INTRODUCTION:
Diffuse idiopathic skeletal hyperostosis (DISH) is a common condition of the adult skeleton where new bone growth occurs in entheseal and bony regions. The cause for the new bone growth is unclear but many lines of evidence point to a role for growth factors linked to abnormal metabolism in these patients. The bone targets for these presumed growth factors are poorly defined. This review summarises the clinical evidence relevant to the sites of origin of new bone formation in DISH to better define potential cellular targets for bone growth in DISH.METHODS:
This is a narrative review of relevant papers identified from searches of PubMed and online journals.RESULTS:
Sites of new bone growth in the enthesis were identified in patients with DISH, with likely cellular targets for growth factors being mesenchymal stem cells in the outer part of the enthesis. Similar undifferentiated skeletal stem cells are present in the outer annulus fibrosis and in the bony eminences of vertebral bodies and other bones, with the potential for response to growth factors.CONCLUSION:
Mesenchymal stem cells are present in specific entheseal and bony locations that are likely responsive to putative growth factors leading to new bone formation characteristic of DISH. Further study of these regions in the context of metabolic abnormalities in DISH will allow for better understanding of the pathophysiology of this common condition.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos y Proteínas de Señalización Intercelular
/
Hiperostosis Esquelética Difusa Idiopática
/
Células Madre Mesenquimatosas
Límite:
Humans
Idioma:
En
Revista:
Semin Arthritis Rheum
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos