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Dimolybdenum (II,II) paddlewheel complexes bearing non-steroidal anti-inflammatory drug ligands: Insights into the chemico-physical profile and first biological assessment.
Chiaverini, Lorenzo; Notarstefano, Valentina; Tolbatov, Iogann; Umari, Paolo; Giorgini, Elisabetta; Ciccone, Lidia; Di Leo, Riccardo; Trincavelli, Letizia; Giacomelli, Chiara; Marchetti, Laura; Marzo, Tiziano; La Mendola, Diego; Marrone, Alessandro.
Afiliación
  • Chiaverini L; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
  • Notarstefano V; Department of Life and Environmental Sciences, DiSVA, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy. Electronic address: v.notarstefano@staff.univpm.it.
  • Tolbatov I; Department of Physics and Astronomy, University of Padova, via F. Marzolo 8, 35131 Padova, Italy; Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, av. Paisos Catalans 16, 43007 Tarragona, Spain. Electronic address: tolbatov.i@gmail.com.
  • Umari P; Department of Physics and Astronomy, University of Padova, via F. Marzolo 8, 35131 Padova, Italy.
  • Giorgini E; Department of Life and Environmental Sciences, DiSVA, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy.
  • Ciccone L; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
  • Di Leo R; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
  • Trincavelli L; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
  • Giacomelli C; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
  • Marchetti L; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
  • Marzo T; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy. Electronic address: tiziano.marzo@unipi.it.
  • La Mendola D; Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.
  • Marrone A; Dipartimento di Farmacia, Università degli Studi "G. D'Annunzio" Chieti-Pescara, Via dei Vestini, 66100 Chieti, Italy.
J Inorg Biochem ; 260: 112697, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39146672
ABSTRACT
Multinuclear complexes are metal compounds featured by adjacent bound metal centers that can lead to unconventional reactivity. Some M2L4-type paddlewheel dinuclear complexes with monoanionic bridging ligands feature promising properties, including therapeutic ones. Molybdenum has been studied for the formation of multiple-bonded M2+ compounds due to their unique scaffold, redox, and spectroscopic properties as well as for applications in several fields including catalysis and biology. These latter are much less explored and only sporadic studies have been carried out. Here, a series of four dimolybdenum (II,II) carboxylate paddlewheel complexes were synthesized using different Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as ligands. The reaction of (NH4)5[Mo2Cl9]·H2O with the selected NSAIDs in methanol produced the complexes Mo2(µ-O2CR)4 where RCO2 is ibuprofen (1), naproxen (2), aspirin (3) and indomethacin (4). The products were obtained in good yields and extensively characterized with integrated techniques. Stability and solution behaviour were studied using a mixed experimental and computational approach. Finally, the biological activity of 1 and 3 (i.e. the most reactive and the most stable compounds of the series, respectively) was preliminarily assessed confirming the disassembling of the molecules in the biological milieu. Overall, some very interesting results emerged for these unconventional compounds from a mechanistic point of view.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Complejos de Coordinación / Molibdeno Límite: Animals / Humans Idioma: En Revista: J Inorg Biochem Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Complejos de Coordinación / Molibdeno Límite: Animals / Humans Idioma: En Revista: J Inorg Biochem Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos