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Effect of combined exposure to phthalates and polycyclic aromatic hydrocarbons during early pregnancy on gestational age and neonatal size: A prospective cohort study.
Hu, Zhongmei; Wu, Nian; An, Songlin; Deng, Mingyu; Tao, Lin; Liao, Dengqing; Yu, Rui; Yang, Jing; Xiao, Yanling; Zheng, Xingting; Zeng, Rong; Liu, Yijun; Xiong, Shimin; Xie, Yan; Liu, Xingyan; Shen, Xubo; Shang, Xuejun; Li, Quan; Zhou, Yuanzhong.
Afiliación
  • Hu Z; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Reproductive Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizho
  • Wu N; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • An S; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • Deng M; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • Tao L; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • Liao D; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • Yu R; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • Yang J; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • Xiao Y; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • Zheng X; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China.
  • Zeng R; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, Guizhou 563000, China.
  • Liu Y; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, Guizhou 563000, China.
  • Xiong S; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, Guizhou 563000, China.
  • Xie Y; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, Guizhou 563000, China.
  • Liu X; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, Guizhou 563000, China.
  • Shen X; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, Guizhou 563000, China.
  • Shang X; Department of Andrology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing 210002, China.
  • Li Q; Department of Obstetrics and Gynecology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, China. Electronic address: 1013283493@qq.com.
  • Zhou Y; School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China; Key Laboratory of Maternal & Child Health and Exposure Science of Guizhou Higher Education Institutes, Zunyi, Guizhou 563000, China. Electronic address: zhouyuanzhong@zmu.edu.cn.
Ecotoxicol Environ Saf ; 284: 116868, 2024 Aug 14.
Article en En | MEDLINE | ID: mdl-39146592
ABSTRACT
Many studies have indicated that individual exposure to phthalates (PAEs) or polycyclic aromatic hydrocarbons (PAHs) affects pregnancy outcomes. However, combined exposure to PAEs and PAHs presents a more realistic situation, and research on the combined effects of PAEs and PAHs on gestational age and newborn size is still limited. This study aimed to assess the effects of combined exposure to PAEs and PAHs on neonatal gestational age and birth size. Levels of 9 PAE and 10 PAH metabolites were measured from the urine samples of 1030 women during early pregnancy from the Zunyi Birth Cohort in China. Various statistical models, including linear regression, restricted cubic spline, Bayesian kernel machine regression, and quantile g-computation, were used to study the individual effects, dose-response relationships, and combined effects, respectively. The results of this prospective study revealed that each ten-fold increase in the concentration of monoethyl phthalate (MEP), 2-hydroxynaphthalene (2-OHNap), 2-hydroxyphenanthrene (2-OHPhe), and 1-hydroxypyrene (1-OHPyr) decreased gestational age by 1.033 days (95 % CI -1.748, -0.319), 0.647 days (95 % CI -1.076, -0.219), 0.845 days (95 % CI -1.430, -0.260), and 0.888 days (95 % CI -1.398, -0.378), respectively. Moreover, when the concentrations of MEP, 2-OHNap, 2-OHPhe, and 1-OHPyr exceeded 0.528, 0.039, 0.012, and 0.002 µg/g Cr, respectively, gestational age decreased in a dose-response manner. Upon analyzing the selected PAE and PAH metabolites as a mixture, we found that they were significantly negatively associated with gestational age, birth weight, and the ponderal index, with 1-OHPyr being the most important contributor. These findings highlight the adverse effects of single and combined exposure to PAEs and PAHs on gestational age. Therefore, future longitudinal cohort studies with larger sample sizes should be conducted across different geographic regions and ethnic groups to confirm the impact of combined exposure to PAEs and PAHs on birth outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ecotoxicol Environ Saf Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ecotoxicol Environ Saf Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos