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A hippocampal circuit mechanism to balance memory reactivation during sleep.
Karaba, Lindsay A; Robinson, Heath L; Harvey, Ryan E; Chen, Weiwei; Fernandez-Ruiz, Antonio; Oliva, Azahara.
Afiliación
  • Karaba LA; Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
  • Robinson HL; Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
  • Harvey RE; Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
  • Chen W; Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
  • Fernandez-Ruiz A; Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
  • Oliva A; Department of Neurobiology and Behavior, Cornell University, Ithaca, NY, USA.
Science ; 385(6710): 738-743, 2024 Aug 16.
Article en En | MEDLINE | ID: mdl-39146421
ABSTRACT
Memory consolidation involves the synchronous reactivation of hippocampal cells active during recent experience in sleep sharp-wave ripples (SWRs). How this increase in firing rates and synchrony after learning is counterbalanced to preserve network stability is not understood. We discovered a network event generated by an intrahippocampal circuit formed by a subset of CA2 pyramidal cells to cholecystokinin-expressing (CCK+) basket cells, which fire a barrage of action potentials ("BARR") during non-rapid eye movement sleep. CA1 neurons and assemblies that increased their activity during learning were reactivated during SWRs but inhibited during BARRs. The initial increase in reactivation during SWRs returned to baseline through sleep. This trend was abolished by silencing CCK+ basket cells during BARRs, resulting in higher synchrony of CA1 assemblies and impaired memory consolidation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Potenciales de Acción / Colecistoquinina / Células Piramidales / Región CA1 Hipocampal / Consolidación de la Memoria Límite: Animals Idioma: En Revista: Science Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño / Potenciales de Acción / Colecistoquinina / Células Piramidales / Región CA1 Hipocampal / Consolidación de la Memoria Límite: Animals Idioma: En Revista: Science Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos