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Gene Expression Profile Identifies LncRNA AL355974.3 As a Potential Glioma Biomarker.
Lu, Hao-Tian; Chen, Yu-Yang; Yu, Yong-Jia; Liao, Xing-Sheng; Liang, Hui; Liang, Lun; Mo, Pan-Lin; Huang, Xin-Kai; Ding, Shuai; Liu, Chang; Feng, Da-Qin.
Afiliación
  • Lu HT; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Chen YY; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Yu YJ; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Liao XS; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Liang H; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Liang L; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Mo PL; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Huang XK; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Ding S; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China.
  • Liu C; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China. 249738984@qq.com.
  • Feng DQ; Department of Neurosurgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, 530021, China. 13807713918@163.com.
Curr Med Sci ; 44(5): 1047-1057, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39145837
ABSTRACT

OBJECTIVE:

Glioma is a central nervous system tumor arising from glial cells. Despite significant advances in diagnosis and treatment, most patients with high-grade gliomas have a poor prognosis. Many studies have shown that long noncoding RNAs (lncRNAs) may play important roles in the development, progression and treatment of many tumors, including gliomas. Molecularly targeted therapy may be a new direction for the adjuvant treatment of glioma. Therefore, we hope that by studying differentially expressed lncRNAs (DElncRNAs) in glioma, we can discover lncRNAs that can serve as biomarkers for glioma and provide better therapeutic modalities for glioma patients.

METHODS:

First, the expression of lncRNAs in 5 normal brain (NB) tissues and 10 glioma tissues was examined by RNA sequencing (RNA-seq). Next, we performed Kaplan-Meier analysis of data from The Cancer Genome Atlas (TCGA) database to assess the prognostic value of these variables. Finally, functional analysis of the DElncRNAs was performed by means of Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.

RESULTS:

RNA sequencing analysis revealed 85 upregulated miRNAs and 71 downregulated lncRNAs in low-grade glioma (LGG) and 50 upregulated lncRNAs and 70 downregulated lncRNAs in glioblastoma (GBM). Among them, AL355974.3 was the most upregulated lncRNA. LINC00632 was the most downregulated lncRNA. Second, LGG patients with higher AL355974.3 expression had worse overall survival according to Kaplan-Meier analysis of the TCGA database. Finally, bioinformatics analysis revealed that the target genes of these DElncRNAs were enriched in various biological processes and signaling pathways, such as cell metabolic and developmental processes.

CONCLUSION:

Our findings provide evidence that AL355974.3 may be a new biomarker for glioma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / ARN Largo no Codificante / Glioma Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Curr Med Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / ARN Largo no Codificante / Glioma Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Curr Med Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China