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RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer.
Liu, Yang; Jiang, Yi; Qiu, Peng; Ma, Tie; Bai, Yang; Bu, Jiawen; Hu, Yueting; Jin, Ming; Zhu, Tong; Gu, Xi.
Afiliación
  • Liu Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
  • Jiang Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
  • Qiu P; Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China.
  • Ma T; Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China.
  • Bai Y; Department of Nursing, Shengjing Hospital of China Medical University, Shenyang, China.
  • Bu J; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
  • Hu Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
  • Jin M; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
  • Zhu T; Breast Surgery of Panjin Central Hospital, Panjin, China.
  • Gu X; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Elife ; 132024 Aug 15.
Article en En | MEDLINE | ID: mdl-39145770
ABSTRACT
Distant metastasis is the major cause of death in patients with breast cancer. Epithelial-mesenchymal transition (EMT) contributes to breast cancer metastasis. Regulator of G protein-signaling (RGS) proteins modulates metastasis in various cancers. This study identified a novel role for RGS10 in EMT and metastasis in breast cancer. RGS10 protein levels were significantly lower in breast cancer tissues compared to normal breast tissues, and deficiency in RGS10 protein predicted a worse prognosis in patients with breast cancer. RGS10 protein levels were lower in the highly aggressive cell line MDA-MB-231 than in the poorly aggressive, less invasive cell lines MCF7 and SKBR3. Silencing RGS10 in SKBR3 cells enhanced EMT and caused SKBR3 cell migration and invasion. The ability of RGS10 to suppress EMT and metastasis in breast cancer was dependent on lipocalin-2 and MIR539-5p. These findings identify RGS10 as a tumor suppressor, prognostic biomarker, and potential therapeutic target for breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Movimiento Celular / Proteínas RGS / Transición Epitelial-Mesenquimal / Metástasis de la Neoplasia Límite: Female / Humans Idioma: En Revista: Elife Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Movimiento Celular / Proteínas RGS / Transición Epitelial-Mesenquimal / Metástasis de la Neoplasia Límite: Female / Humans Idioma: En Revista: Elife Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido