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Coronary Plaque Characterization with T1-weighted MRI and Near-Infrared Spectroscopy to Predict Periprocedural Myocardial Injury.
Isodono, Koji; Matsumoto, Hidenari; Li, Debiao; Slomka, Piotr J; Dey, Damini; Cadet, Sebastien; Irie, Daisuke; Higuchi, Satoshi; Tanisawa, Hiroki; Nakazawa, Motoki; Komori, Yoshiaki; Ohya, Hidefumi; Kitamura, Ryoji; Hondera, Tetsuichi; Sato, Ikumi; Lee, Hsu-Lei; Christodoulou, Anthony G; Xie, Yibin; Shinke, Toshiro.
Afiliación
  • Isodono K; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Matsumoto H; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Li D; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Slomka PJ; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Dey D; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Cadet S; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Irie D; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Higuchi S; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Tanisawa H; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Nakazawa M; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Komori Y; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Ohya H; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Kitamura R; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Hondera T; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Sato I; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Lee HL; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Christodoulou AG; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Xie Y; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
  • Shinke T; From the Departments of Cardiology (K.I., D.I., H.O., R.K.) and Radiological Technology (I.S.), Ijinkai Takeda General Hospital, Kyoto, Japan; Division of Cardiology (H.M., S.H., H.T., M.N., T.S.) and Department of Radiological Technology (T.H.), Showa University School of Medicine, 1-5-8 Hatanodai,
Radiol Cardiothorac Imaging ; 6(4): e230339, 2024 08.
Article en En | MEDLINE | ID: mdl-39145734
ABSTRACT
Purpose To clarify the predominant causative plaque constituent for periprocedural myocardial injury (PMI) following percutaneous coronary intervention (a) erythrocyte-derived materials, indicated by a high plaque-to-myocardium signal intensity ratio (PMR) at coronary atherosclerosis T1-weighted characterization (CATCH) MRI, or (b) lipids, represented by a high maximum 4-mm lipid core burden index (maxLCBI4 mm) at near-infrared spectroscopy intravascular US (NIRS-IVUS). Materials and Methods This retrospective study included consecutive patients who underwent CATCH MRI before elective NIRS-IVUS-guided percutaneous coronary intervention at two facilities. PMI was defined as post-percutaneous coronary intervention troponin T values greater than five times the upper reference limit. Multivariable analysis was performed to identify predictors of PMI. Finally, the predictive capabilities of MRI, NIRS-IVUS, and their combination were compared. Results A total of 103 lesions from 103 patients (median age, 72 years [IQR, 64-78]; 78 male patients) were included. PMI occurred in 36 lesions. In multivariable analysis, PMR emerged as the strongest predictor (P = .001), whereas maxLCBI4 mm was not a significant predictor (P = .07). When PMR was excluded from the analysis, maxLCBI4 mm emerged as the sole independent predictor (P = .02). The combination of MRI and NIRS-IVUS yielded the largest area under the receiver operating curve (0.86 [95% CI 0.64, 0.83]), surpassing that of NIRS-IVUS alone (0.75 [95% CI 0.64, 0.83]; P = .02) or MRI alone (0.80 [95% CI 0.68, 0.88]; P = .30). Conclusion Erythrocyte-derived materials in plaques, represented by a high PMR at CATCH MRI, were strongly associated with PMI independent of lipids. MRI may play a crucial role in predicting PMI by offering unique pathologic insights into plaques, distinct from those provided by NIRS. Keywords Coronary Plaque, Periprocedural Myocardial Injury, MRI, Near-Infrared Spectroscopy Intravascular US Supplemental material is available for this article. © RSNA, 2024.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectroscopía Infrarroja Corta / Placa Aterosclerótica / Intervención Coronaria Percutánea Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Radiol Cardiothorac Imaging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espectroscopía Infrarroja Corta / Placa Aterosclerótica / Intervención Coronaria Percutánea Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Radiol Cardiothorac Imaging Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos