Your browser doesn't support javascript.
loading
Rescue Lead Implantation After Deep Brain Stimulation for Parkinson's Disease: A Single-Center Experience and Case Series.
Schnurman, Zane; Fazl, Arash; Feigin, Andrew S; Mogilner, Alon Y; Pourfar, Michael.
Afiliación
  • Schnurman Z; Department of Neurosurgery, NYU Langone Health, New York, New York, USA.
  • Fazl A; Department of Neurology, Booth Gardner Parkinson's Care Center, EvergreenHealth, Kirkland, Washington.
  • Feigin AS; Department of Neurology, NYU Langone Health, New York, New York, USA.
  • Mogilner AY; Department of Neurosurgery, NYU Langone Health, New York, New York, USA.
  • Pourfar M; Department of Neurosurgery, NYU Langone Health, New York, New York, USA.
Oper Neurosurg (Hagerstown) ; 27(3): 295-302, 2024 Sep 01.
Article en En | MEDLINE | ID: mdl-39145662
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Despite the well-established efficacy of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's Disease (PD), there remains a subset of patients with only a moderate improvement in symptoms even with appropriate lead placement and optimal programming. In patients with persistent tremor or dyskinesias, one consideration is the addition of a second "rescue lead" to provide dual stimulation to primary and secondary targets to address the refractory component. This study aimed to assess all "rescue lead" cases from our institution and characterize the patients and their outcomes.

METHODS:

Records of all patients with PD treated at our institution between 2005 and 2023 were retrospectively reviewed. Clinical data of all patients treated with a second rescue lead to supplement a positive but inadequate initial DBS response were collected and reviewed.

RESULTS:

Of 670 patients with PD treated at our institution during the study period, 7 were managed with a rescue lead. All 7 were initially treated with STN DBS with a partial improvement in underlying symptoms, had confirmed appropriate lead placement, and underwent thorough programming. Four patients underwent rescue with a globus pallidus interna lead for persistent dyskinesias, all with subsequent improvement in their dyskinesias. Three patients had persistent tremors that were treated with a rescue ventrointermediate thalamus stimulation with subsequent improvement in tremor scores. There were no operative complications, and all patients tolerated dual stimulation.

CONCLUSION:

For a small subset of patients with PD with persistent dyskinesias or tremors after STN DBS despite optimized lead parameters and adequate lead placement, rescue lead placement offers an effective treatment option.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Núcleo Subtalámico / Estimulación Encefálica Profunda Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Oper Neurosurg (Hagerstown) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Núcleo Subtalámico / Estimulación Encefálica Profunda Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Oper Neurosurg (Hagerstown) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos