Your browser doesn't support javascript.
loading
Unraveling Cross-Organ Impacts of Airborne Pollutants: A Multiomics Study on Respiratory Exposure and Gastrointestinal Health.
Liu, Bailiang; Wang, Ge; Wang, Lina; Yan, Jiaqian; Zhu, Ke; Liu, Qing; Zhao, Jinzhuo; Jia, Boyue; Fang, Mingliang; Rudich, Yinon; Morawska, Lidia; Chen, Jianmin.
Afiliación
  • Liu B; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China.
  • Wang G; Institute of Eco-Chongming (IEC), Shanghai 202162, China.
  • Wang L; Department of Environmental Hygiene, School of Public Health, Fudan University, Shanghai 200030, China.
  • Yan J; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China.
  • Zhu K; Institute of Eco-Chongming (IEC), Shanghai 202162, China.
  • Liu Q; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China.
  • Zhao J; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China.
  • Jia B; SCIEX, Shanghai 200050, China.
  • Fang M; Department of Environmental Hygiene, School of Public Health, Fudan University, Shanghai 200030, China.
  • Rudich Y; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China.
  • Morawska L; Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention (LAP3), Department of Environmental Science and Engineering, Fudan University, Shanghai 200438, China.
  • Chen J; Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Environ Sci Technol ; 58(35): 15511-15521, 2024 Sep 03.
Article en En | MEDLINE | ID: mdl-39145585
ABSTRACT
Poor air quality is increasingly linked to gastrointestinal diseases, suggesting a potential correlation with human intestine health. However, this relationship remains largely unexplored due to limited research. This study used a controlled mouse model exposed to cooking oil fumes (COFs) and metagenomics, transcriptomics, and metabolomics to elucidate interactions between intestine microbiota and host metabolism under environmental stress. Our findings reveal that short-term COF inhalation induces pulmonary inflammation within 3 days and leads to gastrointestinal disturbances, elucidating a pathway connecting respiratory exposure to intestinal dysfunction. The exposure intensity significantly correlates with changes in intestinal tissue integrity, microbial composition, and metabolic function. Extended exposure of 7 days disrupts intestine microbiota and alters tryptophan metabolism, with further changes observed after 14 days, highlighting an adaptive response. These results highlight the vulnerability of intestinal health to airborne pollutants and suggest a pathway through which inhaled pollutants may affect distant organ systems.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Atmosféricos Límite: Animals Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes Atmosféricos Límite: Animals Idioma: En Revista: Environ Sci Technol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos