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Hematological Second Primary Malignancy in Pediatric Retinoblastoma: A Case Report and Systematic Review.
Hyun Park, Seung; Young Park, Hyun; Kim, Heejin; Woo Han, Jung; Sook Yoon, Jin.
Afiliación
  • Hyun Park S; Department of Medicine, Yonsei University College of Medicine.
  • Young Park H; Department of Ophthalmology, Institute of Vision Research, Severance Hospital.
  • Kim H; Department of Pathology, Yonsei University College of Medicine.
  • Woo Han J; Division of Pediatric Hematology and Oncology, Department of Pediatrics, Yonsei University College of Medicine.
  • Sook Yoon J; Department of Pediatric Haemato-Oncology, Yonsei Cancer Centre, Yonsei University Health System, Seoul, Republic of Korea.
Ophthalmic Plast Reconstr Surg ; 40(5): 487-496, 2024.
Article en En | MEDLINE | ID: mdl-39145503
ABSTRACT

PURPOSE:

The impact of heredity and treatment modalities on the development of hematologic second primary malignancies (SPMs) is unclear. This study primarily reviewed the literature on patients with hematologic SPMs after retinoblastoma.

METHODS:

The PubMed and Web of Science databases were searched to identify all cases of hematologic SPMs after retinoblastoma through December 2023 (International prospective register of systematic reviews CRD42023488273).

RESULTS:

Sixty-one patients from 35 independent publications and our case were included. Within the cohort, 15 patients (51.7%) were male, and 14 patients (48.3%) were female. Of the 43 cases with known heritability status, 27 (62.8%) were classified as heritable and 16 (37.2%) as nonheritable. The median age at diagnosis was 18 months (IQR 7.00-36.00). The geographic distribution of patients was diverse, with North America accounting for 35.0% (21/60) of cases. The following treatment strategies were used 11.9% (5/42) of patients received neither chemotherapy nor radiotherapy, 33.3% (14/42) received chemotherapy alone, 11.9% (5/42) received radiotherapy alone, and 42.9% (18/42) received a combination of chemotherapy and radiotherapy. The median delay between retinoblastoma diagnosis and SPM diagnosis was 40 months (IQR 22.00-85.00). Among the 61 cases, acute myeloid leukemia accounted for 44.3% (27/61), followed by acute lymphoblastic leukemia in 21.3% (13/61), Hodgkin's lymphoma in 11.5% (7/61), non-Hodgkin's lymphoma in 9.8% (6/61), chronic myeloid leukemia in 3.3% (2/61), and acute natural killer cell leukemia in 1.6% (1/61).

CONCLUSIONS:

Vigilant systemic surveillance for hematologic SPMs in retinoblastoma survivors, especially those treated with systemic chemotherapy and those with hereditary conditions, is warranted to improve management strategies and patient outcomes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retinoblastoma / Neoplasias Primarias Secundarias / Neoplasias de la Retina Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Ophthalmic Plast Reconstr Surg Asunto de la revista: OFTALMOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Retinoblastoma / Neoplasias Primarias Secundarias / Neoplasias de la Retina Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Ophthalmic Plast Reconstr Surg Asunto de la revista: OFTALMOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos