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Mitragyna parvifolia as apotential therapeutic agent for lymphatic filariasis.
Jebaseelan, Jefrillah; Sadiq, Sheerin Banu; Ravikumar, Abi Prakathi; Annaraj, Jamespandi; Balakrishnan, Anand Setty.
Afiliación
  • Jebaseelan J; Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India.
  • Sadiq SB; Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India.
  • Ravikumar AP; Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, India.
  • Annaraj J; Department of Materials Science, School of Chemistry, Madurai Kamaraj University, Madurai, India.
  • Balakrishnan AS; Department of Epidemiology and Public Health, Central University of Tamilnadu, Thiruvarur, India.
J Parasit Dis ; 48(3): 474-484, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39145368
ABSTRACT
This study investigates the medicinal potential of Mitragyna parvifolia (M. parvifolia) leaves for the management of Lymphatic filariasis (LF). Phytochemical screening of the methanolic leaf extract revealed the presence of alkaloids, terpenoids, phenols, tannins, and flavonoids. The GC-MS analysis identified 24 phytoconstituents, including the major alkaloid "mitraphylline." Infrared spectroscopy confirmed the presence of various functional groups corresponding to the identified compounds. The extract exhibited significant antibacterial activity against Staphylococcus epidermidis, Bacillus cereus, and Salmonella typhi. In vitro macrofilaricidal screening demonstrated dose-dependent inhibition of worm motility and MTT reduction, indicating its potential as a macrofilaricidal agent. The larvicidal bioassay showed notable effectiveness against Culex quinquifasciatus larvae, with 1% concentration displaying the highest larvicidal activity. Concentration-dependent antioxidant activity was observed using the DPPH assay, with 100 µg/ml showing the highest antioxidant potential. The findings suggest the potential of M. parvifolia leaves for LF management, supporting further research to identify active compounds and elucidate their mechanisms of action. The study highlights the plant's diverse bioactive compounds, antibacterial and macrofilaricidal activities, larvicidal efficacy, and significant antioxidant properties. Future investigations, including in vivo experiments and clinical trials, are warranted to validate the safety and efficacy of M. parvifolia as a potential therapeutic agent for LF.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Parasit Dis Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: India
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Parasit Dis Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: India