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Remote Assessment of Negative Symptoms of Schizophrenia.
Daniel, David G; Cohen, Alex S; Velligan, Dawn; Harvey, Phillip D; Alphs, Larry; Davidson, Michael; Potter, William; Kott, Alan; Schooler, Nina; Brodie, Christopher R; Moore, Raeanne C; Lindenmeyer, Pierre; Marder, Stephen R.
Afiliación
  • Daniel DG; Signant Health, Mclean, VA, USA.
  • Cohen AS; Louisiana State University, Baton Rouge, LA, USA.
  • Velligan D; University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Harvey PD; University of Miami, Miami, FL, USA.
  • Alphs L; Research Service, Bruce W. Carter VA Medical Center, Miami, FL, USA.
  • Davidson M; Denovo BioPharma, San Diego, CA, USA.
  • Potter W; Minerva Neurosciences, Inc, Burlington, MA, USA.
  • Kott A; Independent Expert, Philadelphia, PA, USA.
  • Schooler N; Signant Health, Prague, Czech Republic.
  • Brodie CR; SUNY Downstate Medical Center, Brooklyn, NY, USA.
  • Moore RC; Otsuka Pharmaceutical Development and Commercialization, Inc, Princeton, NJ, USA.
  • Lindenmeyer P; University of California San Diego, San Diego, CA, USA.
  • Marder SR; Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Schizophr Bull Open ; 4(1): sgad001, 2023 Jan.
Article en En | MEDLINE | ID: mdl-39145343
ABSTRACT
In contrast to the validated scales for face-to-face assessment of negative symptoms, no widely accepted tools currently exist for remote monitoring of negative symptoms. Remote assessment of negative symptoms can be broadly divided into 3 categories (1) remote administration of an existing negative-symptom scale by a clinician, in real time, using videoconference technology to communicate with the patient; (2) direct inference of negative symptoms through detection and analysis of the patient's voice, appearance, or activity by way of the patient's smartphone or other device; and (3) ecological momentary assessment, in which the patient self-reports their condition upon receipt of periodic prompts from a smartphone or other device during their daily routine. These modalities vary in cost, technological complexity, and applicability to the different negative-symptom domains. Each modality has unique strengths, weaknesses, and issues with validation. As a result, an optimal solution may be more likely to employ several techniques than to use a single tool. For remote assessment of negative symptoms to be adopted as primary or secondary endpoints in regulated clinical trials, appropriate psychometric standards will need to be met. Standards for substituting 1 set of measures for another, as well as what constitutes a "gold" reference standard, will need to be precisely defined and a process for defining them developed. Despite over 4 decades of progress toward this goal, significant work remains to be done before clinical trials addressing negative symptoms can utilize remotely assessed secondary or primary outcome measures.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Schizophr Bull Open Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Schizophr Bull Open Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos