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Bronchoscopy-Guided High-Power Microwave Ablation in an in vivo Porcine Lung Model.
Sebek, Jan; Goh, Steven; Beard, Warren L; Biller, David S; Hodgson, David S; Highland, Margaret A; Smith, Abbe; Hemphill, Nicholas; Yu, Kun-Chang; Myers, Renelle A; Lam, Stephen; Wibowo, Henky; Prakash, Punit.
Afiliación
  • Sebek J; Mike Wiegers Department of Electrical and Computer Engineering, Kansas State University, Manhattan, KS, USA.
  • Goh S; PhenoMapper, LLC, San Jose, CA, USA.
  • Beard WL; Department of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
  • Biller DS; Department of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
  • Hodgson DS; Department of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
  • Highland MA; Department of Diagnostic Medicine/Pathobiology, Kansas State University, Manhattan, KS, USA.
  • Smith A; Wisconsin Veterinary Diagnostic Laboratory, University of Wisconsin-Madison, Madison, WI, USA.
  • Hemphill N; Broncus Medical, Inc., San Jose, CA, USA.
  • Yu KC; Department of Clinical Sciences, Kansas State University, Manhattan, KS, USA.
  • Myers RA; Broncus Medical, Inc., San Jose, CA, USA.
  • Lam S; Department of Integrative Oncology, British Columbia Cancer Research Center, and The University of British Columbia, Vancouver, BC, Canada.
  • Wibowo H; Department of Integrative Oncology, British Columbia Cancer Research Center, and The University of British Columbia, Vancouver, BC, Canada.
  • Prakash P; PhenoMapper, LLC, San Jose, CA, USA.
Biomed Hub ; 9(1): 108-117, 2024.
Article en En | MEDLINE | ID: mdl-39145138
ABSTRACT

Introduction:

Percutaneous microwave ablation (MWA) is clinically accepted for the treatment of lung tumors and oligometastatic disease. Bronchoscopic MWA is under development and evaluation in the clinical setting. We previously reported on the development of a bronchoscopy-guided MWA system integrated with clinical virtual bronchoscopy and navigation and demonstrated the feasibility of transbronchial MWA, using a maximum power of 60 W at the catheter input. Here, we assessed the performance of bronchoscopy-guided MWA with an improved catheter (maximum power handling of up to 120 W) in normal porcine lung in vivo (as in the previous study).

Methods:

A total of 8 bronchoscopy-guided MWA were performed (n = 2 pigs; 4 ablations per pig) with power levels of 90 W and 120 W applied for 5 and 10 min, respectively. Virtual bronchoscopy planning and navigation guided transbronchial or endobronchial positioning of the MWA applicator for ablation of lung parenchyma. Following completion of ablations and post-procedure CT imaging, the lungs were harvested and sectioned for gross and histopathologic ablation analysis.

Results:

Bronchoscopy-guided MWA with applied energy levels of 90 W/5 min and 120 W/10 min yielded ablation zones with short-axis diameters in the range of 20-28 mm (56-116% increase) as compared to ∼13 mm from our previous study (60 W/10 min). Histology of higher-power and previous lower-power ablations was consistent, including a central necrotic zone, a thermal fixation zone with intact tissue architecture, and a hemorrhagic periphery. Catheter positioning and its confirmation via intra-procedural 3D imaging (e.g., cone-beam CT) proved to be critical for ablation consistency.

Conclusion:

Bronchoscopy-guided MWA with an improved catheter designed for maximum power 120 W yields large ablations in normal porcine lung in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Hub Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Hub Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza