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The disparity of platelet factor 4 and platelets in individuals of different ages.
Weng, Ruopeng; Liu, Jiaqing; Yu, Qingtan; Yuan, Haitao; Qiu, Yun; Liu, Huicong; Wang, Lingna; Mei, Zijie; Zhu, Fangfang.
Afiliación
  • Weng R; Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Liu J; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Yu Q; Department of Laboratory, Qingdao Special Servicemen Recuperation Center of PLA Navy, China.
  • Yuan H; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Qiu Y; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Liu H; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Wang L; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Mei Z; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
  • Zhu F; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Heliyon ; 10(15): e34923, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39145023
ABSTRACT
The aging process profoundly impacts the systemic milieu, with specific blood-borne factors playing critical roles in its regulation. Platelet Factor 4 (PF4), released by platelets, has emerged as a novel blood-borne factor that contributes to the rejuvenation of aging brains in rodents. However, the age-related disparity in PF4 levels in humans remains poorly understood. To explore the relationship between PF4 and the natural aging process in humans, we collected peripheral blood (PB) samples from young (23.40 ± 2.13 years, n = 15) and elderly (75.23 ± 4.19 years, n = 13) individuals, along with cord blood (CB) samples (n = 15). ELISA analysis revealed higher PF4 levels in platelet-rich plasma lysate from young PB compared with that from elderly PB. Consistent with this, qPCR results demonstrated the highest PF4 expression in young PB among the three groups. In addition, FACS analysis showed increased expression of CXCR3 in mononuclear cells of young PB, indicating a greater responsiveness to PF4. Finally, our RNA-sequencing analysis corroborated platelets as a sensitive element during the natural aging process, and indicated platelets play a pivotal role in antioxidant response during aging, as evidenced by significant enrichment of several age-related pathways. These findings reveal that, alongside PF4 levels, platelets undergo substantial alterations during aging. Taken together, our data identified age-related disparities in platelets and PF4-related elements during natural aging and underscored the potential of targeting platelet modulation as an intervention in the aging process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido