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Effects of oral contrast agent on the viscoelastic properties of the terminal ileum investigated using magnetic resonance elastography.
Ro, Sa-Ra; Loch, Florian N; Siegmund, Britta; Kühl, Anja A; Neumann, Gero-Mathias; Hamm, Bernd; Braun, Jürgen; Sack, Ingolf; Reiter, Rolf.
Afiliación
  • Ro SR; Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Loch FN; Institute for Diagnostic and Interventional Radiology, Nuclear Medicine and Molecular Imaging, HELIOS Emil von Behring, Academic Educational Hospital of Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Siegmund B; Department of Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Kühl AA; Department of Gastroenterology, Infectious Disease, Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Neumann GM; iPATH.Berlin-Immunopathology for Experimental Models, Core Facility, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Hamm B; Department of Internal Medicine, Hospital Havelhöhe, Berlin, Germany.
  • Braun J; Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Sack I; Department of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Reiter R; Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Quant Imaging Med Surg ; 14(8): 5973-5982, 2024 Aug 01.
Article en En | MEDLINE | ID: mdl-39144032
ABSTRACT

Background:

While standard clinical magnetic resonance (MR) enterography can detect inflammatory bowel disease, it is of limited value in deciding between medical versus surgical treatment. Alternatively, intestinal MR elastography has the potential to contribute additional information to therapeutic decision-making; however, the influence of bowel distension by oral contrast agent on viscoelastic tissue properties remains elusive. Therefore, we aimed to investigate the influence of oral contrast agent-induced bowel distension on the viscoelastic properties of the terminal ileum in healthy volunteers.

Methods:

In this prospective pilot study, 20 healthy volunteers (33.2±8.2 years; 10 men, 10 women) underwent multifrequency MR elastography using a single-shot spin-echo echo planar imaging sequence at 1.5 Tesla and drive frequencies of 40, 50, 60 and 70 Hz. Maps of shear wave speed (c in ms-1) and loss angle (φ in rad), representing stiffness and viscous properties, respectively, were generated using tomoelastography data processing. The volunteers were scanned before and after ingestion of 1,000 mL of 2% mannitol solution as oral contrast agent.

Results:

There was no significant difference in terminal ileum biomechanical properties before vs. after ingestion of an oral contrast agent (mean c 1.47±0.24 vs. 1.40±0.25 ms-1 with P=0.37; mean φ 0.70±0.12 rad vs. 0.68±0.12 rad with P=0.61). Moreover, there was no statistically significant correlation between MR elastography parameters before and after the ingestion of oral contrast (c r=0.22, P=0.36; φ r=0.24, P=0.30).

Conclusions:

The results of this study suggest that bowel distension for intestinal MR elastography has no systematic effect on the biomechanical tissue properties of the terminal ileum determined by MR elastography. Therefore, future study protocols appear feasible with or without oral contrast agents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Quant Imaging Med Surg Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Quant Imaging Med Surg Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: China