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Blood-brain barrier dysfunction in aging is mediated by brain endothelial senescence.
Novo, João P; Gee, Lucy; Caetano, Carolina A; Tomé, Inês; Vilaça, Andreia; von Zglinicki, Thomas; Moreira, Irina S; Jurk, Diana; Rosa, Susana; Ferreira, Lino.
Afiliación
  • Novo JP; CNC-UC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • Gee L; University of Coimbra, Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Coimbra, Portugal.
  • Caetano CA; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
  • Tomé I; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
  • Vilaça A; CNC-UC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • von Zglinicki T; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
  • Moreira IS; CNC-UC Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
  • Jurk D; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
  • Rosa S; CIBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
  • Ferreira L; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Aging Cell ; : e14270, 2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39143890
ABSTRACT
BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Aging Cell Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Aging Cell Año: 2024 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido