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Expression of Matrix Metalloproteinase-3 in the Aqueous Humor of Patients with Posner-Schlossman Syndrome.
Liu, Yu; Kong, Xiangmei; Teng, Jisen; Wang, Zhujian; Cao, Wenjun.
Afiliación
  • Liu Y; Department of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, China.
  • Kong X; Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
  • Teng J; Department of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, China.
  • Wang Z; Department of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, China.
  • Cao W; Department of Clinical Laboratory, Eye and ENT Hospital of Fudan University, Shanghai, China.
Curr Eye Res ; : 1-4, 2024 Aug 14.
Article en En | MEDLINE | ID: mdl-39143748
ABSTRACT

PURPOSE:

To explore the expression of matrix metalloproteinase-3 (MMP-3) in the aqueous humor of patients with Posner-Schlossman syndrome (PSS), and the association between MMP-3 and PSS.

METHODS:

Peripheral blood and aqueous humor were routinely collected from 29 patients with PSS (PSS group) and 30 patients with age-related-cataract (ARC) (control group). The content of MMP-3 in serum and aqueous humor was measured by immunoturbidimetry. The correlation between MMP-3 and ophthalmic examination results were verified by Spearman's correlation analysis.

RESULTS:

The MMP-3 level in the aqueous humor of the PSS group was (25.86 ± 13.4)ng/ml, significantly higher than that in the control group (3.9 ± 2.7)ng/ml(p < 0.001), while there was no significant difference in serum MMP-3 level between the two groups (p = 0.125). The endothelial cell density (ECD) in the aqueous humor of the PSS group was (2078 ± 440) cell/mm2, intraocular pressure (IOP) in the aqueous humor of the PSS group was (33 ± 12) mmHg. The correlation analysis of aqueous humor MMP-3 and various ophthalmic examination results showed that aqueous humor MMP-3 had a moderate correlation with IOP and the difference in ECD between the affected eye and the fellow eye.

CONCLUSIONS:

MMP-3 level is elevated in the aqueous humor of PSS patients, and it may play an important role in the pathogenesis of PSS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Eye Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Eye Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido