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ncRNA-mediated SOX4 overexpression correlates with unfavorable outcomes and immune infiltration in hepatocellular carcinoma.
Li, Jing; Sun, Xinfeng; Lv, Minling; Han, Zhiyi; Zhong, Xin; Zhang, Wei; Hu, Rui; Feng, Wenxing; Ma, Mengqing; Huang, Qi; Zhou, Xiaozhou.
Afiliación
  • Li J; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
  • Sun X; Department of Liver Disease, The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Lv M; Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao, China.
  • Han Z; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
  • Zhong X; Department of Liver Disease, The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Zhang W; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
  • Hu R; Department of Liver Disease, The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Feng W; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
  • Ma M; Department of Liver Disease, The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
  • Huang Q; Department of Liver Disease, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.
  • Zhou X; Department of Liver Disease, The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
BMC Gastroenterol ; 24(1): 265, 2024 Aug 14.
Article en En | MEDLINE | ID: mdl-39143462
ABSTRACT

BACKGROUND:

The activity and number of immune cells in the tumor microenvironment are closely related to the overall survival of patients with hepatocellular carcinoma (HCC). The sex-determining region Y-box 4 (SOX4) gene is abnormally expressed in various tumor tissues and is critical for tumor development. However, the correlation between SOX4 expression in HCC and tumor immunity is unclear.

METHODS:

SOX4 expression was explored using data from The Cancer Genome Atlas, and UALCAN databases. Real-time reverse transcription quantitative and western blotting were used to analyze SOX4 expression in several liver cancer cell lines. Additionally, correlations among SOX4 expression, cancer immune characteristics, and infiltrated immune cell gene marker sets in patients with HCC were analyzed using data from the Tumor Immune Estimation Resource, Gene Expression Profiling Interactive Analysis, and Tumor-Immune System Interactions databases. Moreover, we evaluated SOX4 expression in HCC tissues and the correlation of SOX4 expression with survival rate. Subsequently, noncoding RNAs (ncRNAs) responsible for SOX4 overexpression were identified using expression, correlation, and survival analyses.

RESULTS:

SOX4 expression was significantly upregulated in HCC and correlated with a poor prognosis. Additionally, SOX4 upregulation in HCC positively correlated with immune cell infiltration, several biomarkers of immune cells, and immune checkpoint expression. Finally, the MCM3AP-AS1/hsa-miR-204-5p axis was identified as the most likely upstream ncRNA-related pathway for SOX4 in HCC. These results indicated that ncRNA-mediated upregulation of SOX4 correlated with the immune infiltration level and poor prognosis in HCC. Our findings provide new directions for the development of novel immunotherapeutic targets for HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Regulación hacia Arriba / Carcinoma Hepatocelular / Factores de Transcripción SOXC / Neoplasias Hepáticas Límite: Female / Humans / Male Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regulación Neoplásica de la Expresión Génica / Regulación hacia Arriba / Carcinoma Hepatocelular / Factores de Transcripción SOXC / Neoplasias Hepáticas Límite: Female / Humans / Male Idioma: En Revista: BMC Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido