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Mapping associations of polygenic scores with autistic and ADHD traits in a single city region.
Reed, Zoe E; Thomas, Richard; Boyd, Andy; Griffith, Gareth J; Morris, Tim T; Rai, Dheeraj; Manley, David; Davey Smith, George; Davis, Oliver S P.
Afiliación
  • Reed ZE; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Thomas R; School of Psychological Science, University of Bristol, Bristol, UK.
  • Boyd A; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Griffith GJ; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Morris TT; Department of Population Health Sciences, ALSPAC, Bristol Medical School, University of Bristol, Bristol, UK.
  • Rai D; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Manley D; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Davey Smith G; Centre for Longitudinal Studies, Social Research Institute, University College London, London, UK.
  • Davis OSP; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
J Child Psychol Psychiatry ; 2024 Aug 14.
Article en En | MEDLINE | ID: mdl-39143033
ABSTRACT

BACKGROUND:

The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants?

METHODS:

We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N = 4,255-6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD.

RESULTS:

Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences.

CONCLUSIONS:

These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Child Psychol Psychiatry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Child Psychol Psychiatry Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido