[Endometrial carcinoma: molecular classification in routine pathology]. / Endometriumkarzinom: molekulare Klassifikation in der Routinepathologie.
Pathologie (Heidelb)
; 45(5): 347-354, 2024 Sep.
Article
en De
| MEDLINE
| ID: mdl-39141093
ABSTRACT
The molecular classification of endometrial carcinoma defines four main groups polymeraseÉ(PolE) gene mutated, microsatellite unstable (MSI), p53 abnormal tumors and tumors with no specific molecular profile (NSMP). This classification provides significant insights into the prognosis and therapeutic decisions. Each group exhibits unique genetic profiles identified through immunohistochemistry and molecular diagnostics, enabling personalized treatment. The identification of these molecular signatures necessitates precise analytical methods, selected based on the local circumstances at each site. The approach to molecular classification highlights the critical role of pathology in the diagnosis and emphasizes the necessity of collaboration between the clinic and pathology.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Endometriales
/
Inestabilidad de Microsatélites
Límite:
Female
/
Humans
Idioma:
De
Revista:
Pathologie (Heidelb)
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Alemania